| Bromophenol derivatives from the red alga Rhodomela confervoides | |
Zhao, JL; Fan, X; Wang, SJ ; Li, SA; Shang, SQ; Yang, YC; Xu, NJ; Lu, Y; Shi, JG; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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| 2004-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 67期号:6页码:1032-1035 |
| 文章类型 | Article |
| 摘要 | Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2",3',3"-tribromo-4",5',5"-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms.; Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2",3',3"-tribromo-4",5',5"-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms. |
| 关键词 | Odonthalia-corymbifera Polysiphonia-urceolata Methyltransferase Inhibitors Larix Acids |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np030546+ |
| URL | 查看原文 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000222277100022 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/1888 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, JL,Fan, X,Wang, SJ,et al. Bromophenol derivatives from the red alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(6):1032-1035. |
| APA | Zhao, JL.,Fan, X.,Wang, SJ.,Li, SA.,Shang, SQ.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2004).Bromophenol derivatives from the red alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,67(6),1032-1035. |
| MLA | Zhao, JL,et al."Bromophenol derivatives from the red alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 67.6(2004):1032-1035. |
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