| Sesquiterpenes from Laurencia similis | |
Su, Hua1,2; Shi, Da-Yong1; Li, Jing1,2 ; Guo, Shu-Ju1,2; Li, Li-Li1,2; Yuan, Zhao-Hui1; Zhu, Xiao-Bin1; Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
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| 2009-05-01 | |
| 发表期刊 | MOLECULES
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| ISSN | 1420-3049 |
| 卷号 | 14期号:5页码:1889-1897 |
| 文章类型 | Article |
| 摘要 | One new sesquiterpene, (4E)-1-bromo-5-[(1'S*, 3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1( 10)-en-9-ol (13), aristolan-1(10), 8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC(50) > 10 mu g/mL).; One new sesquiterpene, (4E)-1-bromo-5-[(1'S*, 3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1( 10)-en-9-ol (13), aristolan-1(10), 8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL). |
| 关键词 | Laurencia Similis Sesquiterpenes Cytotoxic Assay |
| 学科领域 | Chemistry, Organic |
| DOI | 10.3390/molecules14051889 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266381200020 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/1880 |
| 专题 | 海洋生物技术研发中心 实验海洋生物学重点实验室 |
| 通讯作者 | Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Su, Hua,Shi, Da-Yong,Li, Jing,et al. Sesquiterpenes from Laurencia similis[J]. MOLECULES,2009,14(5):1889-1897. |
| APA | Su, Hua.,Shi, Da-Yong.,Li, Jing.,Guo, Shu-Ju.,Li, Li-Li.,...&Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.(2009).Sesquiterpenes from Laurencia similis.MOLECULES,14(5),1889-1897. |
| MLA | Su, Hua,et al."Sesquiterpenes from Laurencia similis".MOLECULES 14.5(2009):1889-1897. |
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