Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata

doi:10.1021/np404499d

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	Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata
	Song, FH ; Fan, X ; Xu, XL ; Zhao, JL ; Yang, YC ; Shi, JG ; Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
	2004-10-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	67 期号:10 页码:1644-1649
文章类型	Article
摘要	Seven new cadinane sesquiterpenes, (-)-(1R,6S,7S,10R)-1-hydroxycadinan-3-en-5-one (1), (+)-(1R,5S,6R,7S, 10R)-cadinan-3-ene-1,5-diol (2), (+)-(1R,5R,6R,7S,10R)-cadinan-3-ene-1,5-diol (3), (+)-(1R,5S,6R,7S,10R)-cadinan-4(11)-ene-1,5-diol (4), (+)-(1R,5R,6R,7R,10R)-cadinan-4(11)-ene-1,5,12-triol (5), (-)-(1R,4R,5S,6R,7S, 10R)-cadinan-1,4,5-triol (6), and (-)-(1R,6R,7S,10R)-11-oxocadinan-4-en-1-ol (7), together with nine known compounds were isolated from the brown alga Dictyopteris divaricata. The structures of the new natural products, as well as their absolute configuration, were established by means of spectroscopic data including IR, HRMS, 1D and 2D NMR, single-crystal X-ray diffraction, and CD. All compounds were inactive against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), breast cancer (MCF-7), hepatoma (Bel7402), and colon cancer (HCT-8) cell lines.; Seven new cadinane sesquiterpenes, (-)-(1R,6S,7S,10R)-1-hydroxycadinan-3-en-5-one (1), (+)-(1R,5S,6R,7S, 10R)-cadinan-3-ene-1,5-diol (2), (+)-(1R,5R,6R,7S,10R)-cadinan-3-ene-1,5-diol (3), (+)-(1R,5S,6R,7S,10R)-cadinan-4(11)-ene-1,5-diol (4), (+)-(1R,5R,6R,7R,10R)-cadinan-4(11)-ene-1,5,12-triol (5), (-)-(1R,4R,5S,6R,7S, 10R)-cadinan-1,4,5-triol (6), and (-)-(1R,6R,7S,10R)-11-oxocadinan-4-en-1-ol (7), together with nine known compounds were isolated from the brown alga Dictyopteris divaricata. The structures of the new natural products, as well as their absolute configuration, were established by means of spectroscopic data including IR, HRMS, 1D and 2D NMR, single-crystal X-ray diffraction, and CD. All compounds were inactive against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), breast cancer (MCF-7), hepatoma (Bel7402), and colon cancer (HCT-8) cell lines.
关键词	Germacrane-type Sesquiterpene Rhodomela-confervoides Marine Plants Benzoic-acid Constituents Zonarioides Hydrocarbons Derivatives
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np404499d
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000224707700002
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/1874
专题	海洋生物技术研发中心
通讯作者	Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Song, FH,Fan, X,Xu, XL,et al. Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata[J]. JOURNAL OF NATURAL PRODUCTS,2004,67(10):1644-1649.
APA	Song, FH.,Fan, X.,Xu, XL.,Zhao, JL.,Yang, YC.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2004).Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata.JOURNAL OF NATURAL PRODUCTS,67(10),1644-1649.
MLA	Song, FH,et al."Cadinane Sesquiterpenes from the brown alga Dictyopteris divaricata".JOURNAL OF NATURAL PRODUCTS 67.10(2004):1644-1649.

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