Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity

doi:10.1021/acs.jafc.3c04601

IOCAS-IR > 实验海洋生物学重点实验室

	Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity
	Liu, Weixiang 1; Qin, Yukun1,2 ; Liu, Song 1,2; Xing, Ronge1,2 ; Yu, Huahua1,2 ; Li, Pengcheng1,2
	2024-02-15
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	72 期号:8 页码:3872-3883
通讯作者	Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
摘要	Herein, a series of chitosan oligosaccharide copper complexes modified with pyridine groups (CPSx-Cu complexes) were successfully prepared via the Schiff base reaction and ion complexation reaction for slow-release fungicide. The structures of the synthesized derivatives were characterized via Fourier transform infrared spectroscopy and 1H and 13C nuclear magnetic resonance spectroscopy, and the unit configuration of the complexes was calculated using Gaussian software. The slow-release performance experiment demonstrated that the cumulative copper ion release rate of CPSx-Cu complexes was dependent on the type of substituents on the pyridine ring. Furthermore, the in vitro and in vivo antifungal activities of the CPSx-Cu complexes were investigated. At a concentration of 0.4 mg/mL, CPSx-Cu complexes completely inhibited the growth of Pythium vexans and Phytophthora capsici. Results indicated that CPSx-Cu complexes with slow-release ability exhibited better antifungal activity than thiodiazole-copper and copper sulfate basic. This study confirmed that combining chitosan oligosaccharide with bioactive pyridine groups and copper ions is an effective approach to further developing slow-release copper fungicides, providing new possibilities for the application of copper fungicides in green agriculture. This study lays the foundation for further studies on biogreen copper fungicides.
关键词	antifungal chitosan oligosaccharide coppercomplex Schiff base slow-release
DOI	10.1021/acs.jafc.3c04601
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42076126] ; Shandong Key R&D Plan, Major Scientific and Technological Innovation Project[2022CXGC020413] ; Shandong Key R&D Plan, Major Scientific and Technological Innovation Project[2023CXGC010412] ; Shandong Provincial Natural Science Foundation[ZR2021QD014] ; Shandong Provincial Natural Science Foundation[ZR2020MD072] ; Shandong Province Science and Technology-Oriented Small and Medium Sized Enterprise Innovation Capability Enhancement Project[2023TSGC0749] ; Liaoning Provincial Natural Science Foundation: Joint Open Fund of the State Key Laboratory for the Creation and Development of New Pesticides[2022-KF-25-03]
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号	WOS:001174775900001
出版者	AMER CHEMICAL SOC
WOS关键词	HUMAN HEALTH ; DERIVATIVES
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184554
专题	实验海洋生物学重点实验室
通讯作者	Qin, Yukun; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Weixiang,Qin, Yukun,Liu, Song,et al. Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024,72(8):3872-3883.
APA	Liu, Weixiang,Qin, Yukun,Liu, Song,Xing, Ronge,Yu, Huahua,&Li, Pengcheng.(2024).Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(8),3872-3883.
MLA	Liu, Weixiang,et al."Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.8(2024):3872-3883.