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Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice
Yang, Yu-Hong1,2; Chen, Chen3,4; Zheng, Yan5; Wu, Zi-Jian3,4; Zhou, Meng-Qing3; Liu, Xiao-Yong2; Miyashita, Kazuo6; Duan, De-Lin7,8; Du, Lei3,4
2024-02-14
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume72Issue:8Pages:4142-4154
Corresponding AuthorDuan, De-Lin(dlduan@qdio.ac.cn) ; Du, Lei(dulei@sdu.edu.cn)
AbstractThe purpose of this study was to evaluate the preventive role and underlying mechanisms of fucoxanthin (Fx) on dextran sulfate sodium (DSS)-induced colitis in mice. The present data demonstrated that oral administration of Fx (50 and 200 mg/kg body weight/day) for 36 days significantly alleviated the severity of colitis in DSS-treated mice, as evidenced by attenuating body weight loss, bloody stool, diarrhea, shortened colon length, colonic epithelium distortion, a thin mucus layer, goblet cell depletion, damaged crypts, and extensive infiltration of inflammatory cells in the colonic mucosa. Additionally, Fx notably relieved DSS-induced intestinal epithelial barrier dysfunction via maintaining the tight junction function and preventing excessive apoptosis of colonic epithelial cells. Moreover, Fx effectively diminished colonic inflammation and oxidative stress in DSS-treated mice, and its mechanisms might be due to blunting the activation of NF-kappa B and NLRP3 inflammasome signaling pathways. Furthermore, Fx also modulates DSS-induced gut microbiota dysbiosis via recovering the richness and diversity of gut microbiota and reshaping the structure of gut microbiota, such as increasing the Firmicutes and Bacteroidota (F/B) ratio and elevating the relative abundance of some potential beneficial bacteria, including Lactobacillaceae and Lachnospiraceae. Overall, Fx might be developed as a promising functional ingredient to prevent colitis and maintain intestinal homeostasis.
Keywordfucoxanthin colitis intestinal barrier function anti-inflammation antioxidation gut microbiota
DOI10.1021/acs.jafc.3c08811
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[32202023] ; National Natural Science Foundation of China[82003447] ; National Natural Science Foundation of China[ZR2021QC177] ; Natural Science Foundation of Shandong Province
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:001167224000001
PublisherAMER CHEMICAL SOC
WOS KeywordNF-KAPPA-B ; OXIDATIVE STRESS ; INTESTINAL BARRIER ; ULCERATIVE-COLITIS ; IBD ; MECHANISMS ; APOPTOSIS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/184506
Collection实验海洋生物学重点实验室
Corresponding AuthorDuan, De-Lin; Du, Lei
Affiliation1.Qilu Univ Technol, Shandong Acad Sci, Sch Food Sci & Engn, Jinan 250353, Shandong, Peoples R China
2.Shandong Haizhibao Ocean Sci & Technol Co Ltd, Rongcheng City 264300, Shandong, Peoples R China
3.Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Dept Nutr & Food Hyg, Jinan 250012, Shandong, Peoples R China
4.Shandong Univ, Jinan Cent Hosp, Res Ctr Translat Med, Jinan 250013, Shandong, Peoples R China
5.Shandong First Med Univ, Res Ctr Translat Med, Cent Hosp, Jinan 250013, Shandong, Peoples R China
6.Obihiro Univ Agr & Vet Med, Ctr Ind Univ Collaborat, Obihiro, Hokkaido 0808555, Japan
7.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Shandong Prov Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China
8.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Yu-Hong,Chen, Chen,Zheng, Yan,et al. Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2024,72(8):4142-4154.
APA Yang, Yu-Hong.,Chen, Chen.,Zheng, Yan.,Wu, Zi-Jian.,Zhou, Meng-Qing.,...&Du, Lei.(2024).Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,72(8),4142-4154.
MLA Yang, Yu-Hong,et al."Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 72.8(2024):4142-4154.
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