Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis

doi:10.1016/j.jprot.2023.105048

IOCAS-IR > 实验海洋生物学重点实验室

	Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis
	Yu, Chunlin1,3 ; Yin, Xiujing 1,3; Li, Aoyu 1,3; Li, Rongfeng 1,2; Yu, Huahua1,2 ; Xing, Ronge1,2 ; Liu, Song 1,2; Li, Pengcheng1,2
	2024-02-10
发表期刊	JOURNAL OF PROTEOMICS
ISSN	1874-3919
卷号	292 页码:13
通讯作者	Yu, Huahua(yuhuahua@qdio.ac.cn)
摘要	Toxin metalloproteinases are the primary components responsible for various toxicities in jellyfish venom, and there is still no effective specific therapy for jellyfish stings. The comprehension of the pathogenic mechanisms underlying toxin metalloproteinases necessitates further refinement. In this study, we conducted a differential analysis of a dermatitis mouse model induced by jellyfish Nemopilema nomurai venom (NnNV) samples with varying levels of metalloproteinase activity. Through skin tissue proteomics and serum metabolomics, the predominant influence of toxin metalloproteinase activity on inflammatory response was revealed, and the signal pathway involved in its regulation was identified. In skin tissues, many membrane proteins were significantly down-regulated, which might cause tissue damage. The expression of pro-inflammatory factors was mainly regulated by PI3K-Akt signaling pathway. In serum, many fatty acid metabolites were significantly down regulated, which might be the anti-inflammation feedback regulated by NF-kappa B p65 signaling pathway. These results reveal the dermatitis mechanism of toxin metalloproteinases and provide new therapeutic targets for further studies.Significance: Omics is an important method to analyze the pathological mechanism and discover the key markers, which can reveal the pathological characteristics of jellyfish stings. Our research first analyzed the impact of toxin metalloproteinases on jellyfish sting dermatitis by skin proteomics and serum metabolomics. The present results suggest that inhibition of toxin metalloproteinases may be an effective treatment strategy, and provide new references for further jellyfish sting studies.
关键词	Jellyfish sting Metalloproteinase Differential analysis Signal pathway Dermatitis mechanism
DOI	10.1016/j.jprot.2023.105048
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42306143] ; National Natural Science Foundation of China[41776163] ; National Natural Science Foundation of China[41876164] ; China Postdoctoral Science Foundation[2023M733532] ; National Key R&D Program of China[2019YFC0312605] ; National Key R&D Program of China[2017YFE0111100-04] ; Natural Science Foundation of Shandong Province[ZR2019QD012] ; Postdoctoral Project Foundation of Qingdao[QDBSH20220202179]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemical Research Methods
WOS记录号	WOS:001124796400001
出版者	ELSEVIER
WOS关键词	NEMOPILEMA-NOMURAI SCYPHOZOA ; CHIRONEX-FLECKERI ; YELLOW SEA ; PROTEIN ; VENOM ; RHIZOSTOMEAE ; ADHESION ; MODULATION ; MUTATIONS ; FAMILY
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184177
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yu, Chunlin,Yin, Xiujing,Li, Aoyu,et al. Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis[J]. JOURNAL OF PROTEOMICS,2024,292:13.
APA	Yu, Chunlin.,Yin, Xiujing.,Li, Aoyu.,Li, Rongfeng.,Yu, Huahua.,...&Li, Pengcheng.(2024).Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis.JOURNAL OF PROTEOMICS,292,13.
MLA	Yu, Chunlin,et al."Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis".JOURNAL OF PROTEOMICS 292(2024):13.