Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight

doi:10.1016/j.scitotenv.2023.168338

	Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight
	Lin, Jiang 1; Chi, Lianbao 2; Yuan, Qing 3; Li, Busu 4; Feng, Mingbao 1
	2024-01-15
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
卷号	908 页码:8
通讯作者	Li, Busu(libusu1616@163.com)
摘要	The ubiquitous existence of various pharmaceuticals in the marine environment has received global attention for their risk assessment. However, rather little is known thus far regarding the natural attenuation (e.g., photolysis) -induced product/mixture toxicity of these pharmaceuticals on marine organisms. In this study, the photo -degradation behavior, product formation, and risks of two representative pharmaceuticals (i.e., ciprofloxacin, CIP; diclofenac, DCF) were explored in the simulated estuary water. It was noted that both pharmaceuticals can be completely photolyzed within 1 h, and five products of CIP and three products of DCF were identified by a high-resolution liquid chromatography-mass spectrometer. Accordingly, their photodecomposition pathways were tentatively proposed. The in silico prediction suggested that the formed transformation products maintained the persistence, bioaccumulation potential, and multi-endpoint toxic effects such as genotoxicity, developmental toxicity, and acute/chronic toxicity on different aquatic species. Particularly, the non-targeted metabolomics first elucidated that DCF and its photolytic mixtures can significantly affect the antioxidant status of marine algae (Heterosigma akashiwo), triggering oxidative stress and damage to cellular components. It is very alarming that the complete photolyzed DCF sample induced more serious oxidative stress than DCF itself, which called for more concern about the photolysis-driven ecological risks. Overall, this investigation first uncoveredthe overlooked but serious toxicity of the transformation products of prevalent pharmaceuticals during natural attenuation on marine species.
关键词	Pharmaceutical contamination Estuarine water Photodegradation pathways Transformation risks Metabolomics
DOI	10.1016/j.scitotenv.2023.168338
收录类别	SCI
语种	英语
资助项目	President's Research Funds from Xiamen University[20720210081]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:001111535000001
出版者	ELSEVIER
WOS关键词	PHOTO-TRANSFORMATION PRODUCTS ; FLUOROQUINOLONE ANTIBIOTICS ; LIQUID-CHROMATOGRAPHY ; DEGRADATION KINETICS ; MARINE-ENVIRONMENT ; SALICYLIC-ACID ; BY-PRODUCTS ; DICLOFENAC ; PHOTOTRANSFORMATION ; CIPROFLOXACIN
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184065
专题	海洋生态与环境科学重点实验室
通讯作者	Li, Busu
作者单位	1.Xiamen Univ, Coll Environm & Ecol, Xiamen 361100, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.China United Engn Corp Ltd, Hangzhou 310052, Peoples R China 4.Laoshan Lab, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Lin, Jiang,Chi, Lianbao,Yuan, Qing,et al. Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2024,908:8.
APA	Lin, Jiang,Chi, Lianbao,Yuan, Qing,Li, Busu,&Feng, Mingbao.(2024).Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight.SCIENCE OF THE TOTAL ENVIRONMENT,908,8.
MLA	Lin, Jiang,et al."Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight".SCIENCE OF THE TOTAL ENVIRONMENT 908(2024):8.