Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom

doi:10.1016/j.ijbiomac.2023.127449

IOCAS-IR > 实验海洋生物学重点实验室

	Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom
	Li, Aoyu 1,2,3; Yue, Yang1 ; Li, Rongfeng 1,2; Yu, Chunlin1,2 ; Wang, Xueqin 1,2; Liu, Song 1,2; Xing, Ronge1,2 ; Li, Pengcheng1,2 ; Zhang, Quanbin 1; Yu, Huahua1,2
	2023-12-31
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	253 页码:13
通讯作者	Yu, Huahua(yuhuahua@qdio.ac.cn)
摘要	Jellyfish dermatitis is a common medical problem caused by jellyfish stings. However, there are no targeted and effective medications for their treatment. Here, the biological activity of fucoidan for treatment of jellyfish dermatitis was investigated for the first time. 3 mg/mL Fucoidan attenuated the inflammatory effects of Nemopilema nomurai nematocyst venom (NnNV), including dermal toxicity and myotoxicity. Fucoidan may decrease the inflammatory effects of NnNV by downregulating MAPK and NF-kappa B pathways. This may be attributed to the inhibitory effect of fucoidan on metalloproteinases and phospholipase A2 (PLA2) in NnNV. 3 mg/mL fucoidan reduced the metalloproteinase activity in NnNV from 316.33 +/- 20.84 U/mg to 177.33 +/- 25.36 U/mg, while the inhibition of PLA2 activity in NnNV by 1 mg/mL fucoidan could reach 37.67 +/- 3.42 %. Besides, external application of 3 mg/mL fucoidan can effectively alleviate the symptoms of jellyfish dermatitis. These observations suggest that fucoidan has considerable potential for treatment of jellyfish dermatitis and could be regarded as a novel medicine for jellyfish envenomation. This study provides new ideas for treatment of jellyfish envenomation and suggests evidence for the use of fucoidan in the treatment of jellyfish dermatitis as well as broadens the potential application of fucoidan in clinical practice.
关键词	Fucoidan Jellyfish dermatitis Jellyfish envenomation
DOI	10.1016/j.ijbiomac.2023.127449
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41776163] ; National Natural Science Foundation of China[41876164] ; National Key Research and Development Program of China[2019YFC0312605] ; National Key Research and Development Program of China[2017YFE0111100- 04] ; Natural Science Foundation of Shandong Province[ZR2019QD012]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001102037000001
出版者	ELSEVIER
WOS关键词	SULFATED POLYSACCHARIDE ; SCYPHOZOA ; DISCHARGE ; CNIDARIA
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183859
专题	实验海洋生物学重点实验室
通讯作者	Yu, Huahua
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Aoyu,Yue, Yang,Li, Rongfeng,et al. Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,253:13.
APA	Li, Aoyu.,Yue, Yang.,Li, Rongfeng.,Yu, Chunlin.,Wang, Xueqin.,...&Yu, Huahua.(2023).Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,253,13.
MLA	Li, Aoyu,et al."Fucoidan may treat jellyfish dermatitis by inhibiting the inflammatory effect of jellyfish venom".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 253(2023):13.

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