Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber

doi:10.1016/j.envpol.2023.121766

	Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber
	Huo, Da 1,2,3,4,6; Zhang, Libin 1,2,3,4,5,6; Yang, Hongsheng1,2,3,4,5,6,7 ; Sun, Lina 1,2,3,4,5,6,7,8
	2023-08-01
发表期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
卷号	330 页码:9
通讯作者	Sun, Lina(sunlina@qdio.ac.cn)
摘要	Low dissolved oxygen (LO) in seawater negatively affects aquatic animals , has received considerable attention. However, there is still much to learn about how echinoderms, which are keystone species in benthic ecosystems, respond to hypoxic stress. Here, we detected differentially expressed metabolites (DEMs) in sea cucumber (Apositchopus japonicus) between normoxic conditions (NC group) and hypoxic conditions (2 mg L-1) for 3 and 7 days (i.e., LO3 and LO7 groups). A total of 243, 298 , 178 DEMs were found in the NC versus LO3, NC vs. LO7, and LO3 vs. LO7 comparisons, respectively. Amino acids were the most abundant class of DEMs, and "biosynthesis of amino acids" was an enriched pathway in all three comparisons. Most of the enriched metabolite sets under hypoxic stress were related to metabolism. As the duration of the hypoxia treatment extended, the metabolism-related process maintained an upward trend, and signaling pathways maintained a downward trend. Thus, metabolism-related processes are affected in hypoxia-stressed sea cucumber, and amino acid metabolism is the most important process for adaption to hypoxic conditions, potentially function in osmotic regulation and energy regulation. Our results shed light on the adaptative strategies of sea cucumber to challenging environ-mental conditions.
关键词	Hypoxic stress Environmental stress Apostichopus japonicus Metabolome Amino acids
DOI	10.1016/j.envpol.2023.121766
收录类别	SCI
语种	英语
资助项目	National Key R & D Pro- gram of China[2022YFF0802202] ; National Natural Science Foundation of China[42106106] ; National Natural Science Foundation of China[42261160378] ; Key Research and Development Program of Shandong, China[2021LZGC029] ; Shandong Provincial Natural Science Foundation, China[ZR2021QD013] ; Postdoctoral Innovative Talents Support Program of Shandong Province, China[SDBX2020006] ; Special Research Assistant Project of Chinese Academy of Sciences, China
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:001001711000001
出版者	ELSEVIER SCI LTD
WOS关键词	APOSTICHOPUS-JAPONICUS ; ALANINE ; OSMOREGULATION ; EXPRESSION ; RESPONSES ; GLYCINE ; INJURY ; ARGININE ; GROWTH ; OXYGEN
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183242
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 7.Chinese Acad Sci, Innovat Seed Design, Wuhan 430071, Peoples R China 8.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
通讯作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Huo, Da,Zhang, Libin,Yang, Hongsheng,et al. Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber[J]. ENVIRONMENTAL POLLUTION,2023,330:9.
APA	Huo, Da,Zhang, Libin,Yang, Hongsheng,&Sun, Lina.(2023).Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber.ENVIRONMENTAL POLLUTION,330,9.
MLA	Huo, Da,et al."Adaptation to hypoxic stress involves amino acid metabolism: A case in sea cucumber".ENVIRONMENTAL POLLUTION 330(2023):9.