IOCAS-IR  > 海洋生态与环境科学重点实验室
Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam
Hu, Zhi1,2,3,4,5,6,7; Xu, Li5,8; Song, Hao2,3,4,5,7; Feng, Jie1,2,3,4,5,7; Zhou, Cong1,2,3,4,5,6; Yang, Mei-Jie1,2,3,4,5,7; Shi, Pu1,2,3,4,5,6,7; Li, Yong-Ren9; Guo, Yong-Jun9; Li, Hai-Zhou1; Zhang, Tao1,2,3,4,5,7
2023-04-01
Source PublicationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
ISSN1532-0456
Volume266Pages:9
Corresponding AuthorZhang, Tao(tzhang@qdio.ac.cn)
AbstractAquatic animals suffer from heat and hypoxia stress more frequently due to global climate change and other anthropogenic activities. Heat and hypoxia stress can significantly affect mitochondrial function and energy metabolism. Here, the response and adaptation characteristics of mitochondria and energy metabolism in the gill of the hard clam Mercenaria mercenaria under heat (35 degrees C), hypoxia (0.2 mg/L), and heat plus hypoxia stress (35 degrees C, 0.2 mg/L) after 48 h exposure were investigated. Mitochondrial membrane potentials were depolarized under environmental stress. Mitochondrial fusion, fission and mitophagy played a key role in maintain mito-chondrion function. The AMPK subunits showed different expression under environmental stress. Acceleration of enzyme activities (phosphofructokinase, pyruvate kinase and lactic dehydrogenase) and accumulation of anaerobic metabolites in glycolysis and TCA cycle implied that the anaerobic metabolism might play a key role in providing energy. Accumulation of amino acids might help to increase tolerance under heat and heat combined hypoxia stress. In addition, urea cycle played a key role in amino acid metabolism to prevent ammonia/nitrogen toxicity. This study improved our understanding of the mitochondrial and energy metabolism responses of marine bivalves exposed to environmental stress.
KeywordMercenaria mercenaria Heat Hypoxia Mitochondrion Energy metabolism
DOI10.1016/j.cbpc.2023.109556
Indexed BySCI
Language英语
Funding ProjectTianjin science and technology commission project[20YFZCSN00240] ; Tianjin Agricultural Committee Project[202103010] ; Tianjin Agricultural Committee Project[SF1405303301] ; Shandong Province Agricultural Major Applied Technology Innovation Project ; Taishan Industrial Leading Talents Project[LMEES-CTSP-2018-1] ; Double Hundred' Blue Industry Leader Team of Yantai ; Creative Team Project of the Laboratory for Marine Ecology and Environ-mental Science, Qingdao Pilot National Laboratory for Marine Science and Technology[2021QNRC001] ; Young Elite Scientists Sponsorship Program by CAST[CARS-49] ; [LJNY201704]
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Toxicology ; Zoology
WOS IDWOS:000995226300001
PublisherELSEVIER SCIENCE INC
WOS KeywordKEY SENSOR ; AMPK ; TEMPERATURE ; EXPRESSION ; RESPONSES ; OYSTER ; OXYGEN
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/183063
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang, Tao
Affiliation1.Inst Oceanol, Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Lab Marine Ecol & Environm Sci, Qingdao Natl Lab Marine Sci & Technol, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
7.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
8.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua ecol & Aquaculture, Tianjin 300384, Peoples R China
9.Shandong Fu Han Ocean Scitech Co Ltd, Haiyang 265100, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Zhi,Xu, Li,Song, Hao,et al. Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2023,266:9.
APA Hu, Zhi.,Xu, Li.,Song, Hao.,Feng, Jie.,Zhou, Cong.,...&Zhang, Tao.(2023).Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,266,9.
MLA Hu, Zhi,et al."Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 266(2023):9.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Zhi]'s Articles
[Xu, Li]'s Articles
[Song, Hao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Zhi]'s Articles
[Xu, Li]'s Articles
[Song, Hao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Zhi]'s Articles
[Xu, Li]'s Articles
[Song, Hao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.