A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury

doi:10.1016/j.algal.2023.103107

IOCAS-IR > 实验海洋生物学重点实验室

	A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury
	Liu, Yang Doris 1,2,3,5; He, Jun 4; Luan, Weiying1,2,3,6 ; Xu, Yanfeng 4; Li, Qianqian1,2,3,7,8 ; Pan, Lishan 4; Liu, Jianguo 1,2,3,9
	2023-05-01
发表期刊	ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
ISSN	2211-9264
卷号	72 页码:10
通讯作者	Liu, Jianguo(jgliu@qdio.ac.cn)
摘要	Astaxanthin was established to conserve kidney function and subcellular structure through anti-oxidation and/or the free radical scavenging system, yet little research linked a new protective effect to autophagy or lysosomes. We pre-fed Wistar rats with natural astaxanthin, beta-carotene, or placebo and induced acute kidney injury using gentamicin, before examining renal tissues and measuring physiological indices. Qualitative evidence from histopathological and subcellular images, along with quantitative evidence showing treatment effects on blood urea nitrogen and serum creatinine (p < 0.01), indicated that esterified Haematococcus astaxanthin surpassed beta-carotene at effectively counteracting chemical damage and protecting the kidneys from injury. Proliferation of enlarged lysosomes and mediation analysis results revealing enhanced lysosomal acid phosphatase activity were consistent with the hypothesized autophagy-lysosomal pathway being up-regulated by astaxanthin intake (p < 0.05). In conclusion, the protective effect of astaxanthin against acute kidney injury exerted through the autophagy-lysosomal detoxification pathway, which totally different from the anti-oxidation and/or conventional SOD-dependent free radical scavenging system, was demonstrated with strong evidence. In light of the pandemic outbreak of novel coronavirus pneumonia associated with a virus preferentially targeting the renal tubular cells, dietary astaxanthin may help bring down incidence rate of coronavirus disease, cases of acute kidney injury secondary to the disease, and mortality rate from acute kidney injury, especially when a standard of care treatment for the infectious disease is pending.
关键词	Acid phosphatase Haematococcus astaxanthin Autophagy Coronavirus Kidney injury Lysosome
DOI	10.1016/j.algal.2023.103107
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences, China[XDB42000000] ; TS Industrial Experts Programme[LJNY202102] ; Laboratory for Marine Biology and Biotechnology of Qingdao National Laboratory for Marine Science and Technology[MS2019N001] ; Chinese Academy of Sciences Biological Resources Service Network Initiative[ZSTH-024]
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000988564100001
出版者	ELSEVIER
WOS关键词	BLOOD MONONUCLEAR-CELLS ; OXIDATIVE STRESS ; IN-VITRO ; INDUCED NEPHROTOXICITY ; PLASMA APPEARANCE ; MERCURIC-CHLORIDE ; BETA-CAROTENE ; LOCALIZATION ; NEPHROPATHY ; CORONAVIRUS
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183051
专题	实验海洋生物学重点实验室
通讯作者	Liu, Jianguo
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao 266071, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Inst Lab Anim Sci, Ctr Safety Evaluat & Res Drugs, Beijing 100021, Peoples R China 5.Univ British Columbia, Fac Med, Vancouver, BC V6T 1Z3, Canada 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Guangzhou 510650, Peoples R China 8.Chinese Acad Sci, South China Bot Garden, Key Lab South China Agr Plant Mol Anal & Genet Imp, Guangzhou 510650, Peoples R China 9.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Liu, Yang Doris,He, Jun,Luan, Weiying,et al. A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2023,72:10.
APA	Liu, Yang Doris.,He, Jun.,Luan, Weiying.,Xu, Yanfeng.,Li, Qianqian.,...&Liu, Jianguo.(2023).A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,72,10.
MLA	Liu, Yang Doris,et al."A new autophagy-driven protective pathway of Haematococcus astaxanthin against chemical damage in wistar rats with gentamicin-induced acute kidney injury".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 72(2023):10.