DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR

doi:10.3389/fmars.2023.1170565

	DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR
	Wu, Tianzhen 1,4; Lei, Yanli1,3,4 ; Jian, Zhimin 2
	2023-05-02
发表期刊	FRONTIERS IN MARINE SCIENCE
卷号	10 页码:9
通讯作者	Lei, Yanli(leiyanli@qdio.ac.cn) ; Jian, Zhimin(jian@tongji.edu.cn)
摘要	DNA damage response (DDR) is a complicated network to defend against physical or chemical changes in DNA in all animals. Elevated levels of ultraviolet radiation (UVR) caused DNA damage, which was a reason for the mass extinction that occurred at the Devonian/Carboniferous (D/C) boundary approximately 359 million years ago (Ma). However, the molecular adaptation of the stony coral ancestors that strangely survived the D/C boundary mass extinction is not well understood. In the present study, the molecular clock analysis using fourfold degenerate sites of 1,463 homologous genes of different stony coral species (a representative group of marine organisms with calcareous skeletons) suggested that their common ancestors originated 384.24 Ma, i.e., slightly earlier than the D/C transition. We identified 21 rapidly evolving genes (REGs) and 49 positive selection genes (PSGs) that were significantly enriched in diverse pathways, including the mitotic cell cycle process, intracellular protein transport, and DNA synthesis involved in DNA repair. Interestingly, four REGs and 21 PSGs were significantly enriched in DDR pathways, including the mitotic cell cycle process, DNA synthesis involved in DNA repair, and cellular response to DNA damage stimulus pathways. We hypothesize that enriched DDR genes are likely involved in the enhanced ability of ancient stony corals to detect and repair DNA damage. For example, the DNA polymerase epsilon catalytic subunit (POLE) gene, which encodes the DNA polymerase epsilon catalytic subunit A, mediates interaction with the other three catalytic subunits through its nonenzymatic carboxy-terminal domain. POLE may potentially enhance the binding ability to other subunits to strengthen its function because eight positive selection sites were distributed in the C-terminal of POLE and on the surface of the simulated 3D protein model. Therefore, our results demonstrated for the first time that the precise transfer of DNA information may help stony coral ancestors survive in elevated levels of ultraviolet radiation, suggesting that DDR levels may be critical to the environmental adaptation of calcareous skeletal organisms during climate change.
关键词	stony coral ancestors ultraviolet radiation DNA damage repair positive selection mass extinction calcareous skeleton organisms
DOI	10.3389/fmars.2023.1170565
收录类别	SCI
语种	英语
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS类目	Environmental Sciences ; Marine & Freshwater Biology
WOS记录号	WOS:000987163200001
出版者	FRONTIERS MEDIA SA
WOS关键词	ULTRAVIOLET-RADIATION ; CLIMATE-CHANGE ; DAMAGE ; DIVERGENCE ; REPLICATION ; SUPEROXIDE ; STRESS ; REEFS
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183012
专题	海洋生物分类与系统演化实验室
通讯作者	Lei, Yanli; Jian, Zhimin
作者单位	1.Inst Oceanol, Chinese Acad Sci, Lab Marine Organism Taxon & Phylogeny, Qingdao Key Lab Marine Biodivers & Conservat, Qingdao, Peoples R China 2.Tongji Univ, State Key Lab Marine Geol, Shanghai, Peoples R China 3.Southern Marine Sci & Engn Guangdong Lab Zhuhai, Zhuhai, Peoples R China 4.Univ Chinese Acad Sci, Coll Marine Sci, Beijing, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wu, Tianzhen,Lei, Yanli,Jian, Zhimin. DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR[J]. FRONTIERS IN MARINE SCIENCE,2023,10:9.
APA	Wu, Tianzhen,Lei, Yanli,&Jian, Zhimin.(2023).DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR.FRONTIERS IN MARINE SCIENCE,10,9.
MLA	Wu, Tianzhen,et al."DNA repair-related genes are the key for stony coral ancestors to survive under elevated levels of UVR".FRONTIERS IN MARINE SCIENCE 10(2023):9.