Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum

doi:10.1021/acs.jnatprod.3c00087

IOCAS-IR

	Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum
	Qi, Yu 1; Wang, Zhongle 1; Zhang, Jingwen 1; Tang, Shuhua 1; Zhu, Haoyun 1; Jiang, Bing 1; Li, Xinhua 1; Wang, Jiabao 1; Sun, Zhongmin 2; Zhao, Min 1; Zhu, Haoru 1; Yan, Pengcheng 1
	2023-05-03
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
页码	10
通讯作者	Zhu, Haoru(zhuhaoru@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn)
摘要	Nine new chromane-type meroterpenoids, including the rare nor-meroterpenoid sargasilol A (1) and the eight meroditerpenoids sargasilols B-I (2-9), were isolated from a China Sea collection of the brown alga Sargassum siliquastrum, together with six known analogues (10-15). The structures of the new chromanes were identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1- 3 and 6-15 exhibited inhibition against LPS-induced NO production in BV-2 microglial cells, and 1, with a shorter carbon chain, was the most active one. Compound 1 was established as an anti-neuroinflammatory agent through targeting the IKK/I kappa B/NF-kappa B signaling pathway. As such, the chromanes from brown algae could provide promising anti-neuroinflammatory lead compounds for further structural modification.
DOI	10.1021/acs.jnatprod.3c00087
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Scientific Center of Wenzhou Medical University
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000984340900001
出版者	AMER CHEMICAL SOC
WOS关键词	ANTIOXIDANT ACTIVITY ; MOJABANCHROMANOL ; DERIVATIVES ; DITERPENES ; CHROMENE
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182970
专题	中国科学院海洋研究所
通讯作者	Zhu, Haoru; Yan, Pengcheng
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Qi, Yu,Wang, Zhongle,Zhang, Jingwen,et al. Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum[J]. JOURNAL OF NATURAL PRODUCTS,2023:10.
APA	Qi, Yu.,Wang, Zhongle.,Zhang, Jingwen.,Tang, Shuhua.,Zhu, Haoyun.,...&Yan, Pengcheng.(2023).Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum.JOURNAL OF NATURAL PRODUCTS,10.
MLA	Qi, Yu,et al."Anti-Neuroinflammatory Meroterpenoids from a Chinese Collection of the Brown Alga Sargassum siliquastrum".JOURNAL OF NATURAL PRODUCTS (2023):10.