Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes

doi:10.1093/molbev/msad172

	Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes
	Perez, Maeva 1,2,3; Aroh, Oluchi 4; Sun, Yanan 5; Lan, Yi 1,2; Juniper, Stanley Kim 6; Young, Curtis Robert 7; Angers, Bernard 3; Qian, Pei-Yuan 1,2
	2023-08-03
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	40 期号:8 页码:15
通讯作者	Perez, Maeva(maeva.perez@umontreal.ca) ; Qian, Pei-Yuan(boqianpy@ust.hk)
摘要	The roles of DNA methylation in invertebrates are poorly characterized, and critical data are missing for the phylum Annelida. We fill this knowledge gap by conducting the first genome-wide survey of DNA methylation in the deep-sea polychaetes dominant in deep-sea vents and seeps: Paraescarpia echinospica, Ridgeia piscesae, and Paralvinella palmiformis. DNA methylation calls were inferred from Oxford Nanopore sequencing after assembling high-quality genomes of these animals. The genomes of these worms encode all the key enzymes of the DNA methylation metabolism and possess a mosaic methylome similar to that of other invertebrates. Transcriptomic data of these polychaetes support the hypotheses that gene body methylation strengthens the expression of housekeeping genes and that promoter methylation acts as a silencing mechanism but not the hypothesis that DNA methylation suppresses the activity of transposable elements. The conserved epigenetic profiles of genes responsible for maintaining homeostasis under extreme hydrostatic pressure suggest DNA methylation plays an important adaptive role in these worms.
关键词	epigenomics DNA methylation deep-sea Polychaeta adaptation Nanopore
DOI	10.1093/molbev/msad172
收录类别	SCI
语种	英语
资助项目	Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)[2021HJ01] ; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)[SMSEGL20SC01] ; Major Basic and Applied Research Projects of Guangdong Province[2019B030302004-04] ; GRF ; CRF of HKSAR government[16101822] ; CRF of HKSAR government[C2013-22G] ; Natural Science and Engineering Research Council of Canada[N238600] ; Digital Research Alliance of Canada[4257] ; Natural Science and Engineering Research Council's Alexander Graham Bell fellowship ; Fonds de recherche du Quebec-Nature et Technologie ; Quebec Center
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:001046217200004
出版者	OXFORD UNIV PRESS
WOS关键词	COMPLETE MITOCHONDRIAL GENOME ; DNA CYTOSINE METHYLATION ; CONVERGENT EVOLUTION ; ADAPTATION ; METHIONINE ; INSIGHTS ; TUBEWORM ; METABOLISM ; RETROVIRUS ; GYPSY
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182781
专题	海洋生物分类与系统演化实验室
通讯作者	Perez, Maeva; Qian, Pei-Yuan
作者单位	1.Southern Marine Sci & Engn Guangdong Lab Guangzhou, Guangzhou, Peoples R China 2.Hong Kong Univ Sci & Technol, Dept Ocean Sci, Kowloon, Hong Kong, Peoples R China 3.Univ Montreal, Dept Biol Sci, Montreal, PQ, Canada 4.Auburn Univ, Dept Biol Sci, Auburn, AL USA 5.Chinese Acad Sci, Inst Oceanol, Lab Marine Organism Taxon & Phylogeny, Qingdao, Peoples R China 6.Univ Victoria, Sch Earth & Ocean Sci, Victoria, BC, Canada 7.Natl Oceanog Ctr, Southampton, England
推荐引用方式 GB/T 7714	Perez, Maeva,Aroh, Oluchi,Sun, Yanan,et al. Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes[J]. MOLECULAR BIOLOGY AND EVOLUTION,2023,40(8):15.
APA	Perez, Maeva.,Aroh, Oluchi.,Sun, Yanan.,Lan, Yi.,Juniper, Stanley Kim.,...&Qian, Pei-Yuan.(2023).Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes.MOLECULAR BIOLOGY AND EVOLUTION,40(8),15.
MLA	Perez, Maeva,et al."Third-Generation Sequencing Reveals the Adaptive Role of the Epigenome in Three Deep-Sea Polychaetes".MOLECULAR BIOLOGY AND EVOLUTION 40.8(2023):15.