Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers

doi:10.3390/ijms241512213

	Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers
	Xing, Lili1,2,3 ; Wang, Lingyu 4; Liu, Shilin 1,2,3; Sun, Lina 1,2,3; Wessel, Gary M.5; Yang, Hongsheng1,2,3
	2023-08-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1661-6596
卷号	24 期号:15 页码:18
通讯作者	Sun, Lina(sunlina@qdio.ac.cn) ; Wessel, Gary M.(rhet@brown.edu)
摘要	The sea cucumber Apostichopus japonicus has important nutritional and medicinal value. Unfortunately, we know little of the source of active chemicals in this animal, but the plentiful pigments of these animals are thought to function in intriguing ways for translation into clinical and food chemistry usage. Here, we found key cell groups with the gene activity predicted for the color morphology of sea cucumber body using single-cell RNA-seq. We refer to these cell populations as melanocytes and quinocytes, which are responsible for the synthesis of melanin and quinone pigments, respectively. We integrated analysis of pigment biochemistry with the transcript profiles to illuminate the molecular mechanisms regulating distinct pigment formation in echinoderms. In concert with the correlated pigment analysis from each color morph, this study expands our understanding of medically important pigment production, as well as the genetic mechanisms for color morphs, and provides deep datasets for exploring advancements in the fields of bioactives and nutraceuticals.
关键词	single-cell RNA-seq pigmentation sea cucumber melanin quinone pigments nutritional and medicinal value
DOI	10.3390/ijms241512213
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42106109] ; Natural Science Foundation of Shandong Province Youth Program[ZR2020QD100] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030304] ; Agricultural Seed Project of Shandong Province[2020LZGC015] ; National Institutes of Health USA[1R35GM140897]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:001046297000001
出版者	MDPI
WOS关键词	NEURAL CREST ; MELANIN ; EVOLUTION ; STEM ; SPECIFICATION ; CHIMAPHILIN ; DECREASES ; INDUCTION ; ZEBRAFISH ; QUINONES
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182742
专题	海洋生态与环境科学重点实验室
通讯作者	Sun, Lina; Wessel, Gary M.
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Duke Univ, Dept Biol, Durham, NC 27708 USA 5.Brown Univ, Dept Mol Biol Cellular Biol & Biochem, Providence, RI 02912 USA
第一作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
通讯作者单位	海洋生态与环境科学重点实验室; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xing, Lili,Wang, Lingyu,Liu, Shilin,et al. Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(15):18.
APA	Xing, Lili,Wang, Lingyu,Liu, Shilin,Sun, Lina,Wessel, Gary M.,&Yang, Hongsheng.(2023).Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(15),18.
MLA	Xing, Lili,et al."Single-Cell Transcriptome and Pigment Biochemistry Analysis Reveals the Potential for the High Nutritional and Medicinal Value of Purple Sea Cucumbers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.15(2023):18.