The initial application of conch-shell hydroxyapatite and HACC as functional filler in PMMA bone cement

doi:10.1080/00914037.2023.2243367

IOCAS-IR > 实验海洋生物学重点实验室

	The initial application of conch-shell hydroxyapatite and HACC as functional filler in PMMA bone cement
	Tian, Luqi 1,2,3; Xing, Ronge1,2,4,5,6 ; Yang, Haoyue1,2 ; Liu, Song 1,2,4; Yu, Huahua1,2,4 ; Li, Pengcheng1,2,4
	2023-08-05
发表期刊	INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
ISSN	0091-4037
页码	10
通讯作者	Xing, Ronge(xingronge@qdio.ac.cn)
摘要	In this study, we acquired conch-shell Hydroxyapatite (cHA)with a mean size of 99.41 nm using a microwave-assisted method, and hydroxypropyl trimethyl ammonium chloride chitosan (HACC) with a molecular weight of 41 kDa was synthesized from deacetylated chitosan. These two additives were added to plain PMMA bone cement, improving its biological activity. It was shown that the addition of cHA and HACC balanced the mechanical performance and porosity of the implant, improving its biocompatibility with mouse pre-osteoblasts (MC3T3-E1). A composite cement with 30 wt% cHA and 0.5 wt% HACC significantly enhanced mineralization efficiency, protein adsorption, and alkaline phosphatase (ALP) activity.
关键词	Conch shell HACC hydroxyapatite PMMA bone cement >
DOI	10.1080/00914037.2023.2243367
收录类别	SCI
语种	英语
资助项目	Fujian science and technology planning project-STS program[2021T3013] ; Key deployment projects of the Marine Science Research Center of Chinese Academy of Sciences[COMS2020J04]
WOS研究方向	Materials Science ; Polymer Science
WOS类目	Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:001041713200001
出版者	TAYLOR & FRANCIS AS
WOS关键词	SCAFFOLDS ; BIOACTIVITY
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/182641
专题	实验海洋生物学重点实验室
通讯作者	Xing, Ronge
作者单位	1.Chinese Acad Sci, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 5.Chinese Acad Sci, Qingdao 266071, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Tian, Luqi,Xing, Ronge,Yang, Haoyue,et al. The initial application of conch-shell hydroxyapatite and HACC as functional filler in PMMA bone cement[J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,2023:10.
APA	Tian, Luqi,Xing, Ronge,Yang, Haoyue,Liu, Song,Yu, Huahua,&Li, Pengcheng.(2023).The initial application of conch-shell hydroxyapatite and HACC as functional filler in PMMA bone cement.INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,10.
MLA	Tian, Luqi,et al."The initial application of conch-shell hydroxyapatite and HACC as functional filler in PMMA bone cement".INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2023):10.