Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF

doi:10.1016/j.aquatox.2023.106654

	Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF
	Lai, Kaiqi 1,2,3; Zhang, Libin 1,2,3; Xu, Jialei 4
	2023-09-01
发表期刊	AQUATIC TOXICOLOGY
ISSN	0166-445X
卷号	262 页码:9
通讯作者	Zhang, Libin(zhanglibin@qdio.ac.cn)
摘要	Bisphenols are known as endocrine disruptor that affect the development, and growth of marine creatures, including human. There were plenty of manuscripts evaluated the toxicology of bisphenol A (BPA) and its analogues such as bisphenol F (BPF), bisphenol AF (BPAF), and bisphenol S (BPS), but limits of them studied the effects of bisphenol analogues on echinoderms. In this study, we used metabolomics to investigate the metabolic response of sea cucumber (Apostichopus japonicus) exposed to BPAF, and the activities of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) were determined. The results demonstrated alterations in lipid metabolism, glycerophospholipid metabolism, and biosynthesis of amino acids following BPAF treatment. Sea cucumbers upregulated the glycerophospholipid metabolism to repair the destruction of intestine cellular homeostasis. Six metabolites were selected as the potential biomarkers for the exposure of BPAF. This study revealed the metabolic response and oxidative response of sea cucumber arising from BPAF exposure, and provided theoretical support for the risk assessment of bisphenol analogues on economically important echinoderms, such as A. japonicus.
关键词	Endocrine disruptor Bisphenol AF Sea cucumber Metabolic response Oxidative stress response
DOI	10.1016/j.aquatox.2023.106654
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42061160365]
WOS研究方向	Marine & Freshwater Biology ; Toxicology
WOS类目	Marine & Freshwater Biology ; Toxicology
WOS记录号	WOS:001062311900001
出版者	ELSEVIER
WOS关键词	ACUTE TOXICITY ; ANALOGS ; HEALTH
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181851
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang, Libin
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Tonghe Shandong Ocean Technol Co Ltd, Dongying 257200, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室
通讯作者单位	海洋生态与环境科学重点实验室
推荐引用方式 GB/T 7714	Lai, Kaiqi,Zhang, Libin,Xu, Jialei. Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF[J]. AQUATIC TOXICOLOGY,2023,262:9.
APA	Lai, Kaiqi,Zhang, Libin,&Xu, Jialei.(2023).Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF.AQUATIC TOXICOLOGY,262,9.
MLA	Lai, Kaiqi,et al."Metabolic and oxidative stress response of sea cucumber Apostichopus japonicus exposed to acute high concentration of bisphenol AF".AQUATIC TOXICOLOGY 262(2023):9.