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Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512
Chi, Lu-Ping1,2,3; Liu, Dong1,2; Li, Xiao-Ming1,2; Wan, Yupeng1,2; Wang, Bin-Gui1,2,4; Li, Xin1,2,4
2023-08-31
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume71Issue:36Pages:13316-13324
Corresponding AuthorWang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn)
AbstractMarine fungus-derived natural products are an important source of antimicrobial compounds against marine aquatic pathogens. Here, we describe the isolation and characterization of five new pentadepsipeptides, aspertides A-E (1-5), containing a unique p-methoxycinnamoyl amide group, from the marine fungi Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512. Among them, aspertides B-E (2-5) also possessed uncommon amino acid residues, such as 3-hydroxyproline, 2,3-dihydroxyproline, or pipecolinic acid. The structures of these compounds were elucidated on the basis of NMR and mass spectroscopic analyses. The absolute configurations of them were established by chiral HPLC analyses of the acidic hydrolysates and NMR calculations with DP4+ probability analysis. In bio-activity assays, compounds 4 and 5 exhibited antibacterial activities against aquatic-pathogenic bacteria, including Edwardsiella tarda, Vibrio alginolyticus, Vibrio anguillarum, Vibrio vulnificus, and Staphylococcus aureus, with MIC values of 8-32 mu g/mL.
Keywordmarine-derivedfungi pentadepsipeptides p-methoxycinnamoylamide Aspergillus spp. antimicrobial activity
DOI10.1021/acs.jafc.3c02610
Indexed BySCI
Language英语
Funding ProjectThis work was financially supported by the National Key Ramp;amp;D Program of China (2022YFC2804700), the National Natural Science Foundation of China (32200022, 42076090, and U2006203), and the Shandong Provincial Natural Science Foundation (ZR2021ZD28).
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:001060974700001
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/181809
Collection实验海洋生物学重点实验室
Corresponding AuthorWang, Bin-Gui; Li, Xin
Affiliation1.Chinese Acad Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,et al. Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(36):13316-13324.
APA Chi, Lu-Ping,Liu, Dong,Li, Xiao-Ming,Wan, Yupeng,Wang, Bin-Gui,&Li, Xin.(2023).Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(36),13316-13324.
MLA Chi, Lu-Ping,et al."Aspertides A-E: Antimicrobial Pentadepsipeptides with a Unique p-Methoxycinnamoyl Amide Group from the Marine Isolates Aspergillus tamarii MA-21 and Aspergillus insuetus SD-512".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.36(2023):13316-13324.
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