Metabolic profiling of <i>Apostichopus japonicus</i> body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health

doi:10.3389/fmars.2023.1205538

	*Metabolic profiling of Apostichopus japonicus* body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health**
	Ding, Kui1,2,3 ; Zhuo, Pengji 3,4; Ge, Meiling 1,2; Liao, Xiaomei 1,2; Mo, Jing 1,2; Liu, Shilin 3; Xu, Qinzeng 1,2; Zhang, Xuelei 1,2
	2023-09-28
发表期刊	FRONTIERS IN MARINE SCIENCE
卷号	10 页码:15
通讯作者	Xu, Qinzeng(xuqinzeng@fio.org.cn) ; Zhang, Xuelei(zhangxl@fio.org.cn)
摘要	Introduction: Sea cucumbers are cultivated mainly for their valuable body wall. Polybrominated diphenyl ethers are common persistent pollutants in sea waters with known impacts on aquatic animals nonetheless not yet studied for the body wall of sea cucumbers. Methods: Using ltra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS), we investigated the metabolic impact of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the body wall of Apostichopus japonicus. etabolite changes and metabolic pathway alterations were assessed in response to three distinct concentrations of BDE-47: 0.1 mu g/L, 1.0 mu g/L, and 10.0 mu g/L. REsults: Exposure to BDE-47 led to notable alterations in the metabolic profiles of the body wall. A total of 95 similar to 102 metabolites in the 0.1 similar to 10.0 mu g/L BDE-47 treated group were altered significantly, and various disrupted metabolic pathways were identified and characterized. These metabolites and metabolic pathways were mainly involved in lipid metabolism, energy metabolism, immunity, oxidative stress, inflammation, and neurotoxicity. Discussion: The findings of our study shed light on the potential health risks that polybrominated diphenyl ethers present to sea cucumbers. This underscores the imperative for both researchers and policymakers to delve deeper into further investigations and studies. These results indicate the necessity for enhanced monitoring and management practices within the sea cucumber aquaculture industry to mitigate the impact of these persistent organic pollutants and protect the health and safety of this valuable resource.
关键词	sea cucumber BDE-47 body wall metabolite metabolic pathway
DOI	10.3389/fmars.2023.1205538
收录类别	SCI
语种	英语
资助项目	This research was funded by the National Natural Science Foundation of China (Grant No. 42106131).[42106131] ; National Natural Science Foundation of China
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS类目	Environmental Sciences ; Marine & Freshwater Biology
WOS记录号	WOS:001083319800001
出版者	FRONTIERS MEDIA SA
WOS关键词	POLYBROMINATED DIPHENYL ETHERS ; BROMINATED FLAME RETARDANTS ; 2,2',4,4'-TETRABROMODIPHENYL ETHER ; GREEN TEA ; OXIDATIVE STRESS ; BIOTRANSFORMATION ; IDENTIFICATION ; ACCUMULATION ; MECHANISMS ; RESPONSES
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181629
专题	海洋生态与环境科学重点实验室
通讯作者	Xu, Qinzeng; Zhang, Xuelei
作者单位	1.Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao, Peoples R China 2.Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 4.North China Sea Bur Minist Nat Resources, Marine & Isl Management Dept, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Ding, Kui,Zhuo, Pengji,Ge, Meiling,et al. Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health[J]. FRONTIERS IN MARINE SCIENCE,2023,10:15.
APA	Ding, Kui.,Zhuo, Pengji.,Ge, Meiling.,Liao, Xiaomei.,Mo, Jing.,...&Zhang, Xuelei.(2023).Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health.FRONTIERS IN MARINE SCIENCE,10,15.
MLA	Ding, Kui,et al."Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health".FRONTIERS IN MARINE SCIENCE 10(2023):15.