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Promoter methylation as a potential cause for the decrease in pyruvate metabolism during environmentally induced aestivation in Apostichopus japonicus
Jiang, Chunxi1,2,3; Sun, Lina1,2,3; Yang, Hongsheng1,2,3,4,5
2024-01-30
Source PublicationAQUACULTURE
ISSN0044-8486
Volume579Pages:10
Corresponding AuthorYang, Hongsheng(hshyang@ms.qdio.ac.cn)
AbstractApostichopus japonicus is an important aquaculture species with significant economic value. As water temperatures increase during the summer, A. japonicus enters aestivation to resist adverse environments and maintain survival. The most significant feature of aestivation in sea cucumbers is metabolic depression, but the molecular mechanisms involved in this process are not fully explained. In this study, we analyzed the methylation status and gene expression of intestinal tissues from A. japonicus during aestivation, to reveal the mechanism of metabolic depression involved during aestivation from the perspective of epigenetic modifications. Of the 2886 hypermethylated genes and 1534 hypomethylated genes obtained, methylation and transcriptome correlation analysis identified 207 methylation-driven low-expression candidate genes and 71 methylation-driven highly expressed candidate genes. Analysis of the methylation location showed that 5% of differential methylation occurred in the promoter region; those genes that were differentially methylated in the promoter region were also significantly enriched in the pyruvate metabolic pathway. Metabolite content analysis of the glycolytic pathway and the tricarboxylic acid cycle pathway, key sources and consumption pathways of pyruvate, respectively, showed that the content of these metabolites was significantly reduced, suggesting pyruvate metabolic depression of A. japonicus during aestivation. In conclusion, these results reveal that promoter methylation is likely a potential cause of pyruvate metabolic depression during aestivation in A. japonicus. They also provide new insights into the epigenetic regulation mechanism of hypometabolism during aestivation.
KeywordEnvironmentally induced aestivation Epigenetics Promoter methylation Pyruvate metabolism
DOI10.1016/j.aquaculture.2023.740135
Indexed BySCI
Language英语
Funding ProjectKey Research and Development Pro- gram of Shandong[2021LZGC029] ; National Natural Science Foundation of China[42076093] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24030304]
WOS Research AreaFisheries ; Marine & Freshwater Biology
WOS SubjectFisheries ; Marine & Freshwater Biology
WOS IDWOS:001092917800001
PublisherELSEVIER
WOS KeywordAFRICAN CLAWED FROG ; DNA METHYLATION ; GENE ; EXPRESSION ; SELENKA ; DEPRESSION ; SUMMARIZE ; PROTEINS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/181608
Collection海洋生态与环境科学重点实验室
Corresponding AuthorYang, Hongsheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci & Expt Mari, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci & Marine Biol & Bio, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Key Laboratory of Marine Ecology & Environmental Sciences, CAS
Recommended Citation
GB/T 7714
Jiang, Chunxi,Sun, Lina,Yang, Hongsheng. Promoter methylation as a potential cause for the decrease in pyruvate metabolism during environmentally induced aestivation in Apostichopus japonicus[J]. AQUACULTURE,2024,579:10.
APA Jiang, Chunxi,Sun, Lina,&Yang, Hongsheng.(2024).Promoter methylation as a potential cause for the decrease in pyruvate metabolism during environmentally induced aestivation in Apostichopus japonicus.AQUACULTURE,579,10.
MLA Jiang, Chunxi,et al."Promoter methylation as a potential cause for the decrease in pyruvate metabolism during environmentally induced aestivation in Apostichopus japonicus".AQUACULTURE 579(2024):10.
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