Morphological characteristics of beak-like tooth in spotted knifejaw<i> (Oplegnathus</i><i> punctatus)</i> and mechanisms of dental development regulation by the Wnt, BMP, FGF and SHH signalling pathways

doi:10.1016/j.ijbiomac.2023.126188

IOCAS-IR > 实验海洋生物学重点实验室

	Morphological characteristics of beak-like tooth in spotted knifejaw (Oplegnathus punctatus) and mechanisms of dental development regulation by the Wnt, BMP, FGF and SHH signalling pathways
	Ma, Yuting ; Xiao, Yongshuang 1,2; Xiao, Zhizhong ; Li, Jun 1,2
	2023-10-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	250 页码:19
通讯作者	Xiao, Yongshuang(yongshuangxiao@qdio.ac.cn) ; Li, Jun(yongshuangxiao@qdio.ac.cn)
摘要	Oplegnathus punctatus is a fish species with beak-like tooth that feeds on algae, oysters, sea urchins, and other organisms attached to rocks. Currently, there are no research reports on the development and regulatory mechanisms of O. punctatus beak-like tooth. This present study firstly elucidated the nesting structure pattern of the beak-like tooth with dental formula (4, 15-16, 10-1) for O. punctatus. Four critical periods during early beak-like tooth development (28dph, 40dph, 50dph, 60dph) were also identified. In addition, 11 key genes (bmp2, bmpr2, smad1, wnt5a, msx, axin2, fgfr1a, fgfr2, pitx2, ptch1, cyp27a1) closely related to the development of beak-like tooth were discovered, with the highest expression levels in the initial stages of functional teeth and replacement teeth development, and expression in the mesenchymal and epithelial tissues of the teeth. Further research found that the cyp27a1 gene, related to vitamin D metabolism and calcium accumulation, was expressed in the maxilla and base of the tooth in O. punctatus. This study provides support for the biological theory of tooth development and healing and provides a reference for the adaptive evolution of tooth healing in special habitats.
关键词	Oplegnathus punctatus Beak-like tooth Tooth development Mesenchymal cells BMP Vitamin D metabolism
DOI	10.1016/j.ijbiomac.2023.126188
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42276107] ; National Key Research and Development Program[2022YFC3103600] ; Key Deployment Projects of Center for Ocean Mega-Science, Chinese Academy of Sciences[CARS-47] ; CARs for Marine Fish Culture Industry ; [COMS2020Q05]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001088418700001
出版者	ELSEVIER
WOS关键词	TEETH ; EXPRESSION ; REGENERATION ; PERCIFORMES ; PUFFERFISH ; STRINGTIE ; KNOWLEDGE ; SCARIDAE ; TELEOST ; FISHES
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181605
专题	实验海洋生物学重点实验室
通讯作者	Xiao, Yongshuang; Li, Jun
作者单位	1.Chinese Acad Sci, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Ma, Yuting,Xiao, Yongshuang,Xiao, Zhizhong,et al. Morphological characteristics of beak-like tooth in spotted knifejaw (Oplegnathus punctatus) and mechanisms of dental development regulation by the Wnt, BMP, FGF and SHH signalling pathways[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,250:19.
APA	Ma, Yuting,Xiao, Yongshuang,Xiao, Zhizhong,&Li, Jun.(2023).Morphological characteristics of beak-like tooth in spotted knifejaw (Oplegnathus punctatus) and mechanisms of dental development regulation by the Wnt, BMP, FGF and SHH signalling pathways.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,250,19.
MLA	Ma, Yuting,et al."Morphological characteristics of beak-like tooth in spotted knifejaw (Oplegnathus punctatus) and mechanisms of dental development regulation by the Wnt, BMP, FGF and SHH signalling pathways".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 250(2023):19.

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