Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242

doi:10.1038/s41429-023-00664-5

IOCAS-IR > 实验海洋生物学重点实验室

	Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
	Wang, Ying1,2 ; Ying, Zhen 1,2; Li, Xiao-Ming 1; Yang, Sui-Qun 1; Li, Hong-Lei1 ; Wang, Bin-Gui1,2,3 ; Meng, Ling-Hong1,2
	2023-10-17
发表期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
页码	7
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
摘要	Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (3), together with a known nonadride analogue (4), were characterized from the Magellan Seamount-derived fungus Talaromyces scorteus AS-242. Their structures were established by detailed interpretation of NMR spectroscopic and mass spectrometry data analysis. X-ray crystallographic analysis of compounds 1 and 3 confirmed their structures and absolute configurations, representing the first characterized crystal structure of a nonadride-type polyketide. The isolated compounds exhibited potent antimicrobial activities against the pathogenic bacterium MRSA and V. parahaemolyticus and pathogenic fungi C. gloeosporioides, F. oxysporum, and F. proliferatum, with MIC values ranging from 1 to 64 mu g ml(-1).
DOI	10.1038/s41429-023-00664-5
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Jiangsu Province[BK20201211] ; Senior User Project of RV KEXUE[KEXUE2020GZ02]
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS类目	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS记录号	WOS:001090950000001
出版者	SPRINGERNATURE
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181574
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wang, Ying,Ying, Zhen,Li, Xiao-Ming,et al. Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242[J]. JOURNAL OF ANTIBIOTICS,2023:7.
APA	Wang, Ying.,Ying, Zhen.,Li, Xiao-Ming.,Yang, Sui-Qun.,Li, Hong-Lei.,...&Meng, Ling-Hong.(2023).Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242.JOURNAL OF ANTIBIOTICS,7.
MLA	Wang, Ying,et al."Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242".JOURNAL OF ANTIBIOTICS (2023):7.