A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides

doi:10.1038/s41429-023-00666-3

IOCAS-IR > 实验海洋生物学重点实验室

	A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
	Zhang, Fan-Zhong1,2 ; Li, Xiao-Ming 1,2; Meng, Ling-Hong1,2,3,4 ; Wang, Bin-Gui1,2,3,4
	2023-10-26
发表期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
页码	8
通讯作者	Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Three new compounds, including one steroid named penivariod A (1) and two polyketides penivarides A and B (2 and 3), as well as six known derivatives (4-9) were isolated from Penicillium variabile EN-394, a fungus afforded from the marine red alga Rhodomela confervoides. Their structures were elucidated by analysis of the HRESIMS, 1D and 2D NMR. The absolute stereochemistry was determined by X-ray crystallographic data, gauge-independent atomic orbital (GIAO) NMR shift calculation followed by DP4+ analysis combined with calculated electronic circular dichroism (ECD). Antimicrobial activities for the new compounds (1-3) were evaluated against human-and aquatic-pathogenic bacteria as well as plant pathogenic fungi. Compound 1 exhibited potent antimicrobial activity against most of the pathogenic strains, especially for Escherichia coli and Pseudomonas aeruginosa, with MIC values of 1.0 and 2.0 mu g ml(-1), respectively.
DOI	10.1038/s41429-023-00666-3
收录类别	SCI
语种	英语
资助项目	Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[31600267] ; Financial support from the National Natural Science Foundation of China (31600267 and 42176115) and from the Natural Science Foundation of Jiangsu Province (No. BK20201211) is gratefully acknowledged.[42176115] ; National Natural Science Foundation of China[BK20201211] ; Natural Science Foundation of Jiangsu Province
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS类目	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS记录号	WOS:001089669800001
出版者	SPRINGERNATURE
WOS关键词	A-D ; ASPERGILLUS
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181559
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides[J]. JOURNAL OF ANTIBIOTICS,2023:8.
APA	Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2023).A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides.JOURNAL OF ANTIBIOTICS,8.
MLA	Zhang, Fan-Zhong,et al."A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides".JOURNAL OF ANTIBIOTICS (2023):8.