Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk <i>Lottia peitaihoensis</i>

doi:10.1007/s42995-023-00194-x

IOCAS-IR > 实验海洋生物学重点实验室

	Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk Lottia peitaihoensis
	Tan, Sujian 1; Huan, Pin 1,2; Liu, Baozhong1,2
	2023-10-21
发表期刊	MARINE LIFE SCIENCE & TECHNOLOGY
ISSN	2096-6490
页码	12
通讯作者	Liu, Baozhong(bzliu@qdio.ac.cn)
摘要	The D-quadrant organizer sets up the dorsal-ventral (DV) axis and regulates mesodermal development of spiralians. Studies have revealed an important role of mitogen-activated protein kinase (MAPK) signaling in organizer function, but the related molecules have not been fully revealed. The association between fibroblast growth factor receptor (FGFR) and MAPK signaling in regulating organizer specification has been established in the annelid Owenia fusiformis. Now, comparable studies in other spiralian phyla are required to decipher whether this organizer-inducing function of FGFR is prevalent in Spiralia. Here, we indicate that treatment with the FGFR inhibitor SU5402 resulted in deficiency of organizer specification in the mollusk Lottia peitaihoensis. Subsequently, the bone morphogenetic protein (BMP) signaling gradient and DV patterning were disrupted, suggesting the roles of FGFR in regulating organizer function. Changes in multiple aspects of organizer function (the morphology of vegetal blastomeres, BMP signaling gradient, expression of DV patterning markers, etc.) indicate that these developmental functions have different sensitivities to FGFR/MAPK signaling. Our results reveal a functional role of FGFR in organizer specification as well as DV patterning of Lottia embryos, which expands our knowledge of spiralian organizers.
关键词	FGF signaling Organizer specification BMP signaling gradient DV patterning Mollusk
DOI	10.1007/s42995-023-00194-x
收录类别	SCI
语种	英语
资助项目	The authors thank the two anonymous reviewers for their thoughtful suggestions. This work was supported by the National Natural Science Foundation of China (grant numbers 42206092, 42076123); the Earmarked Fund for China Agriculture Research System (grant[42206092] ; The authors thank the two anonymous reviewers for their thoughtful suggestions. This work was supported by the National Natural Science Foundation of China (grant numbers 42206092, 42076123); the Earmarked Fund for China Agriculture Research System (grant[42076123] ; National Natural Science Foundation of China[CARS-49] ; Earmarked Fund for China Agriculture Research System[LSKJ202203002] ; Marine Samp;T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)
WOS研究方向	Marine & Freshwater Biology
WOS类目	Marine & Freshwater Biology
WOS记录号	WOS:001089179800001
出版者	SPRINGERNATURE
WOS关键词	D-QUADRANT ORGANIZER ; DORSOVENTRAL AXIS ; CELL LINEAGE ; POLAR LOBE ; CLEAVAGE PATTERN ; EMBRYOS ; PATELLOGASTROPODA ; CONSERVATION ; EXPRESSION ; MESODERM
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/181544
专题	实验海洋生物学重点实验室
通讯作者	Liu, Baozhong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Laoshan Lab, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Tan, Sujian,Huan, Pin,Liu, Baozhong. Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk Lottia peitaihoensis[J]. MARINE LIFE SCIENCE & TECHNOLOGY,2023:12.
APA	Tan, Sujian,Huan, Pin,&Liu, Baozhong.(2023).Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk Lottia peitaihoensis.MARINE LIFE SCIENCE & TECHNOLOGY,12.
MLA	Tan, Sujian,et al."Functional evidence that FGFR regulates MAPK signaling in organizer specification in the gastropod mollusk Lottia peitaihoensis".MARINE LIFE SCIENCE & TECHNOLOGY (2023):12.