Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138

doi:10.3390/md20080529

IOCAS-IR > 实验海洋生物学重点实验室

	Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138
	Song, Qi 1,2,3; Yang, Sui-Qun 1,2,4; Li, Xiao-Ming 1,2,4; Hu, Xue-Yi1,2,3 ; Li, Xin1,2,4 ; Wang, Bin-Gui1,2,3,4
	2022-08-01
发表期刊	MARINE DRUGS
卷号	20 期号:8 页码:9
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
摘要	Five new aromatic polyketides, including a unique benzofuran derivative, talarominine A (1), and four chromone analogs talamins A-D (2-5), along with one known related metabolite, 5-hydroxy-7-methoxy-2,3-dimethylchromone (6), were isolated and identified from the Talaromyces minioluteus CS-138, an endozoic fungus obtained from the deep-sea cold seep mussel Gigantidas platifrons. Their chemical structures were elucidated by detailed analysis of their NMR spectra, HRESIMS and X-ray crystallographic data, and by comparison with literature data as well. The antibacterial and DPPH scavenging activities of compounds 1-6 were evaluated. Compounds 1-3 showed inhibitory activity against some of the tested bacteria whereas compounds 2 and 5 showed potent DPPH radical scavenging activities, which were better than that of the positive control butylated hydroxytoluene (BHT). This work is likely the first report on marine natural products of mussel-derived fungus living in cold seep environments.
关键词	Talaromyces minioluteus Gigantidas platifrons deep-sea cold seep antimicrobial activity DPPH scavenging activity
DOI	10.3390/md20080529
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDA22050401] ; National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[82003648] ; National Natural Science Foundation of China[KEXUE2020GZ02]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000845475300001
出版者	MDPI
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180853
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Song, Qi,Yang, Sui-Qun,Li, Xiao-Ming,et al. Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138[J]. MARINE DRUGS,2022,20(8):9.
APA	Song, Qi,Yang, Sui-Qun,Li, Xiao-Ming,Hu, Xue-Yi,Li, Xin,&Wang, Bin-Gui.(2022).Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138.MARINE DRUGS,20(8),9.
MLA	Song, Qi,et al."Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138".MARINE DRUGS 20.8(2022):9.