Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model | |
Wang, Xiaoqing1,2; Wei, Maosheng1,2; Wang, Jing1,3 ; Liu, Jing1,4; Zhang, Quanbin1,3
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| 2022-10-19 | |
| 发表期刊 | AQUACULTURE INTERNATIONAL
 |
| ISSN | 0967-6120 |
| 页码 | 17 |
| 通讯作者 | Liu, Jing(jingwang@qdio.ac.cn) |
| 摘要 | Many carbohydrate compounds derived from marine seaweeds possess immune-enhancing activities. In recent years, the effect of dietary addition of marine polysaccharides on fish has been widely evaluated. Here, we studied the immunoregulation potential of oligo-porphyran (OP) through LPS-induced RAW264.7 cells and zebrafish model. Surprisingly, we found that OP had an excellent anti-inflammatory effect with a dose-dependent manner in vitro. OP administration effectively reduced LPS-induced NO release and inflammatory cytokine production in RAW264.7 cells. Notably, we also found that dietary OP to zebrafish exerted positive effect on intestinal immunity through regulating immune factor content and gut microbiota. Besides, dietary OP could also maintain steadiness of intestinal morphology of zebrafish, enhance the intestinal digestive enzyme activity, and promote the accumulation of crude protein and crude fat in zebrafish. These findings indicated that OP supplementation in diet could promote growth, improve immunity, and regulate intestinal flora, which made OP a promising aquatic candidate additive. |
| 关键词 | Oligo-porphyran Immunological parameters RAW264 7 macrophages Zebrafish model |
| DOI | 10.1007/s10499-022-00999-0 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key research and Development Program of China[2019YFD0900705] |
| WOS研究方向 | Fisheries |
| WOS类目 | Fisheries |
| WOS记录号 | WOS:000870108800001 |
| 出版者 | SPRINGER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/180636 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Jing |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Qingdao Agr Univ, Qingdao, Peoples R China |
| 第一作者单位 | 中国科学院海洋大科学研究中心 |
| 通讯作者单位 | 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,et al. Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model[J]. AQUACULTURE INTERNATIONAL,2022:17. |
| APA | Wang, Xiaoqing,Wei, Maosheng,Wang, Jing,Liu, Jing,&Zhang, Quanbin.(2022).Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model.AQUACULTURE INTERNATIONAL,17. |
| MLA | Wang, Xiaoqing,et al."Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model".AQUACULTURE INTERNATIONAL (2022):17. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| s10499-022-00999-0.p（4064KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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