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Cryptochrome 1 is involved in anti-bacterial immunity in Japanese flounder (Paralichthys olivaceus)
Zhang, Peng1,2,3; Sun, Boguang1,2,4
2022-12-15
发表期刊AQUACULTURE
ISSN0044-8486
卷号561页码:11
通讯作者Sun, Boguang(sunboguang@qdio.ac.cn)
摘要Cryptochrome is a pivotal protein of the core regulatory machinery in circadian clock and participates in various biological processes including immunity. In fish, the immunological functionality of Cryptochrome is unclear. In this study, we profiled the expression pattern of Japanese flounder cryptochrome 1 (named PoCry1) and inves-tigated its involvement in the immune response during bacterial infection. PoCry1 is approximately 75% iden-tical in amino acid sequence to mammalian Cryptochrome 1 and possesses the conserved DNA photolyase domain and FAD binding domain. Its transcription was detected in 10 flounder tissues and was reduced upon Vibrio harveyi challenge. The transcription of PoCry1 exhibited apparent rhythmic oscillation upon the light actuation of a day-night cycle in different tissues. The knockdown of PoCry1 resulted in significant augment of inflammatory cytokine expression. During bacterial infection, PoCry1 silencing led to increase in cytokine expression and decrease in bacterial dissemination, which could be neutralized by a specific PKA inhibitor, suggesting PoCry1 is likely able to negatively modulate the immune response to bacterial infection through PKA associated pathways.Taken together, our results revealed that PoCry1 is circadian oscillated in transcription upon rhythmic light stimulation and involved in anti-infection immunity, thus enlightening that light condition as a circadian zeit-geber could be exploited to strength fish immune system and benefit disease control in aquaculture.
关键词Paralichthys olivaceus Circadian protein Cryptochrome 1 Immune response Bacterial infection
DOI10.1016/j.aquaculture.2022.738675
收录类别SCI
语种英语
资助项目National Key Research and Development Program of China[2018YFD0900500] ; National Natural Science Foundation of China[41876170] ; Taishan Scholar Program of Shandong Province
WOS研究方向Fisheries ; Marine & Freshwater Biology
WOS类目Fisheries ; Marine & Freshwater Biology
WOS记录号WOS:000868091100001
出版者ELSEVIER
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/180621
专题实验海洋生物学重点实验室
通讯作者Sun, Boguang
作者单位1.Chinese Acad Sci, Inst Oceanol, CAS Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Zhang, Peng,Sun, Boguang. Cryptochrome 1 is involved in anti-bacterial immunity in Japanese flounder (Paralichthys olivaceus)[J]. AQUACULTURE,2022,561:11.
APA Zhang, Peng,&Sun, Boguang.(2022).Cryptochrome 1 is involved in anti-bacterial immunity in Japanese flounder (Paralichthys olivaceus).AQUACULTURE,561,11.
MLA Zhang, Peng,et al."Cryptochrome 1 is involved in anti-bacterial immunity in Japanese flounder (Paralichthys olivaceus)".AQUACULTURE 561(2022):11.
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