Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer

doi:10.1016/j.ijbiomac.2022.09.201

IOCAS-IR > 实验海洋生物学重点实验室

	Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer
	Deng, Zhenzhen 1,2,3,4; Wu, Ning 1,2,5; Suo, Qishan 2,4; Wang, Jing1,2,3 ; Yue, Yang1,2,3 ; Geng, Lihua 1,2,3; Zhang, Quanbin 1,2,3
	2022-12-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	222 页码:562-572
通讯作者	Wu, Ning(wuning@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
摘要	Chemotherapy resistance is one of the most critical challenges in colorectal cancer (CRC) treatment. The occurrence and development of chemotherapy resistance closely related to the tumor immune microenvironment (TIME). As the most important immunosuppressive immune cells infiltrating into the TIME, macrophages are essential for chemotherapy resistance in CRC treatment. In this study, we found that a kind of fucoidan (FPS1M) induced macrophages differentiation to the M1 phenotype, and this transformation promoted cancer cells apoptosis both in vitro and in vivo. TNF alpha is a key mediator of FPS1M-induced tumorcidal activity of macrophages. Mechanistically, as a stimulator of TLR4, FPS1M enhanced macrophages glycolysis and regulated macrophages differentiation to the M1 phenotype by the activation of TLR4 mediated PI3K/AKT/mTOR signaling axis. In addition, FPS1M improved the immunosuppressed tumor microenvironment by increasing the infiltration of M1 macrophages in tumor tissue, which was conducive to improving the sensitivity of tumor to chemotherapy. Collectively, our findings demonstrated that FPS1M has the great potential to be used in tumor immunotherapy. The results also suggested that the combination of FPS1M with capecitabine is an alternative therapy method for colon cancer.
关键词	Capecitabine Tumor microenvironment Macrophages TLR4 Fucoidan
DOI	10.1016/j.ijbiomac.2022.09.201
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China ; Major Scientific & Engineering Projects of Innovation in Shandong Province ; [81872906] ; [42176137] ; [2019JZZY010818]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000876352600006
出版者	ELSEVIER
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180540
专题	实验海洋生物学重点实验室
通讯作者	Wu, Ning; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Pilot Natl Lab Marine Sci & Technol, Lab Marine drugs & Biol Prod, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Deng, Zhenzhen,Wu, Ning,Suo, Qishan,et al. Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,222:562-572.
APA	Deng, Zhenzhen.,Wu, Ning.,Suo, Qishan.,Wang, Jing.,Yue, Yang.,...&Zhang, Quanbin.(2022).Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,222,562-572.
MLA	Deng, Zhenzhen,et al."Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 222(2022):562-572.

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