Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa | |
| Yuan, Zihao1,2; Jiang, Shuai1,2; Qin, Kunpeng1,2,3; Sun, Li1,2,3 | |
| 2022-07-22 | |
| Source Publication | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| ISSN | 2296-634X |
| Volume | 10Pages:13 |
| Corresponding Author | Jiang, Shuai(sjiang@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn) |
| Abstract | Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent in a large number of invertebrates. In the lower vertebrate, fish, three types of GSDME, i.e., GSDMEa, GSDMEb, and a previously unreported type (designated GSDMEc), were idenitied. Evolutionarily, the three GSDMEs are distinctly separated: GSDMEa is closely related to tetrapod GSDME; GSDMEb exists exclusively in fish; GSDMEc forms the lineage root of tetrapod GSDMA/B/C/D. GSDMEc shares conserved genomic features with and is probably the prototype of GSDMA, which we found existing in all tetrapod classes. GSDMEc displays fast evolutionary dynamics, likely as a result of genomic transposition. A cross-metazoan analysis of GSDME revealed that GSDMEa shares a conserved caspase recognition motif with the GSDME of tetrapods and cnidarians, whereas GSDMEb has a unique caspase recognition motif similar to that of mammalian GSDMD, and GSDMEc exhibits no apparent caspase recognition motif. Through functional test, four highly conserved residues in vertebrate GSDME proved to be essential to auto-inhibition. Together our results provide new insights into the origin, evolution, and function of metazoan GSDMs. |
| Keyword | metazoan fish gasdermin evolution recognition motif auto-inhibition |
| DOI | 10.3389/fcell.2022.952015 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Marine S&T Fund of Shandong Province[2022QNLM050101] ; National Natural Science Foundation of China[41876175] ; Youth Innovation Promotion Association CAS[2021204] ; Taishan Scholar Program of Shandong Province |
| WOS Research Area | Cell Biology ; Developmental Biology |
| WOS Subject | Cell Biology ; Developmental Biology |
| WOS ID | WOS:000837366300001 |
| Publisher | FRONTIERS MEDIA SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/179864 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Jiang, Shuai; Sun, Li |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, CAS Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,et al. New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10:13. |
| APA | Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,&Sun, Li.(2022).New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10,13. |
| MLA | Yuan, Zihao,et al."New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022):13. |
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