New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa

doi:10.3389/fcell.2022.952015

IOCAS-IR > 实验海洋生物学重点实验室

	New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa
	Yuan, Zihao 1,2; Jiang, Shuai 1,2; Qin, Kunpeng 1,2,3; Sun, Li 1,2,3
	2022-07-22
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
卷号	10 页码:13
通讯作者	Jiang, Shuai(sjiang@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn)
摘要	Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent in a large number of invertebrates. In the lower vertebrate, fish, three types of GSDME, i.e., GSDMEa, GSDMEb, and a previously unreported type (designated GSDMEc), were idenitied. Evolutionarily, the three GSDMEs are distinctly separated: GSDMEa is closely related to tetrapod GSDME; GSDMEb exists exclusively in fish; GSDMEc forms the lineage root of tetrapod GSDMA/B/C/D. GSDMEc shares conserved genomic features with and is probably the prototype of GSDMA, which we found existing in all tetrapod classes. GSDMEc displays fast evolutionary dynamics, likely as a result of genomic transposition. A cross-metazoan analysis of GSDME revealed that GSDMEa shares a conserved caspase recognition motif with the GSDME of tetrapods and cnidarians, whereas GSDMEb has a unique caspase recognition motif similar to that of mammalian GSDMD, and GSDMEc exhibits no apparent caspase recognition motif. Through functional test, four highly conserved residues in vertebrate GSDME proved to be essential to auto-inhibition. Together our results provide new insights into the origin, evolution, and function of metazoan GSDMs.
关键词	metazoan fish gasdermin evolution recognition motif auto-inhibition
DOI	10.3389/fcell.2022.952015
收录类别	SCI
语种	英语
资助项目	Marine S&T Fund of Shandong Province[2022QNLM050101] ; National Natural Science Foundation of China[41876175] ; Youth Innovation Promotion Association CAS[2021204] ; Taishan Scholar Program of Shandong Province
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
WOS记录号	WOS:000837366300001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179864
专题	实验海洋生物学重点实验室
通讯作者	Jiang, Shuai; Sun, Li
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,et al. New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10:13.
APA	Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,&Sun, Li.(2022).New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10,13.
MLA	Yuan, Zihao,et al."New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022):13.