IOCAS-IR  > 实验海洋生物学重点实验室
New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa
Yuan, Zihao1,2; Jiang, Shuai1,2; Qin, Kunpeng1,2,3; Sun, Li1,2,3
2022-07-22
Source PublicationFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN2296-634X
Volume10Pages:13
Corresponding AuthorJiang, Shuai(sjiang@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn)
AbstractGasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent in a large number of invertebrates. In the lower vertebrate, fish, three types of GSDME, i.e., GSDMEa, GSDMEb, and a previously unreported type (designated GSDMEc), were idenitied. Evolutionarily, the three GSDMEs are distinctly separated: GSDMEa is closely related to tetrapod GSDME; GSDMEb exists exclusively in fish; GSDMEc forms the lineage root of tetrapod GSDMA/B/C/D. GSDMEc shares conserved genomic features with and is probably the prototype of GSDMA, which we found existing in all tetrapod classes. GSDMEc displays fast evolutionary dynamics, likely as a result of genomic transposition. A cross-metazoan analysis of GSDME revealed that GSDMEa shares a conserved caspase recognition motif with the GSDME of tetrapods and cnidarians, whereas GSDMEb has a unique caspase recognition motif similar to that of mammalian GSDMD, and GSDMEc exhibits no apparent caspase recognition motif. Through functional test, four highly conserved residues in vertebrate GSDME proved to be essential to auto-inhibition. Together our results provide new insights into the origin, evolution, and function of metazoan GSDMs.
Keywordmetazoan fish gasdermin evolution recognition motif auto-inhibition
DOI10.3389/fcell.2022.952015
Indexed BySCI
Language英语
Funding ProjectMarine S&T Fund of Shandong Province[2022QNLM050101] ; National Natural Science Foundation of China[41876175] ; Youth Innovation Promotion Association CAS[2021204] ; Taishan Scholar Program of Shandong Province
WOS Research AreaCell Biology ; Developmental Biology
WOS SubjectCell Biology ; Developmental Biology
WOS IDWOS:000837366300001
PublisherFRONTIERS MEDIA SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/179864
Collection实验海洋生物学重点实验室
Corresponding AuthorJiang, Shuai; Sun, Li
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,et al. New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2022,10:13.
APA Yuan, Zihao,Jiang, Shuai,Qin, Kunpeng,&Sun, Li.(2022).New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,10,13.
MLA Yuan, Zihao,et al."New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10(2022):13.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan, Zihao]'s Articles
[Jiang, Shuai]'s Articles
[Qin, Kunpeng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan, Zihao]'s Articles
[Jiang, Shuai]'s Articles
[Qin, Kunpeng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan, Zihao]'s Articles
[Jiang, Shuai]'s Articles
[Qin, Kunpeng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.