Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy | |
Gao, Kun1,2; Qin, Yukun1,2![]() ![]() ![]() ![]() ![]() | |
2022-07-25 | |
发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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ISSN | 0021-8561 |
页码 | 16 |
通讯作者 | Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn) |
摘要 | Hymexazol (HYM) is irreplaceable for treating soil-borne diseases due to its high efficiency and low cost, as a broadspectrum fungicide. However, when HYM is absorbed by plants, it is rapidly converted into two glycoside metabolites, and the antifungal activities of these glycosides are inferior to that of HYM. Therefore, in this study, to maintain strong antifungal activity in vitro and in vivo, HYM was glycosylated with amino sugars that have diverse biological activities to simulate plant glycosylation. The antifungal experiment proved that glycoside 15 has the highest antifungal activity, and N-acetyl glucosamine and HYM had obvious synergistic effects. According to the structure-activity relationship studies, glycoside 15 had greater numbers of active electron-rich regions and front-line orbital electrons due to the introduction of N-acetyl glucosamine. Moreover, glycoside 15 can significantly promote plant growth and induce an increase in plant defense enzyme activity. Additionally, compared to HYM, the results of electron microscopy and proteomics revealed that glycoside 15 has a unique antifungal mechanism. The promising antifungal activity and interactions with plants mean that glycoside 15 is a potential green fungicide candidate. Furthermore, this research conducted an interesting exploration of the agricultural applications of amino sugars. |
关键词 | hymexazol glycosylation antifungal DFT proteomics |
DOI | 10.1021/acs.jafc.2c02507 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key R&D Program of China[2019YFD0900705] ; National Natural Science Foundation of China[42076126] ; Shandong Provincial Natural Science Foundation[ZR2020MD072] ; Shandong Provincial Natural Science Foundation[ZR2021QC006] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Qingdao Science and Technology Demonstration and Guidance Project[20-3-4-22-nsh] ; Science and Technology Plan Project of Shinan District, Qingdao[2020-2-013-QT] |
WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
WOS类目 | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
WOS记录号 | WOS:000834104900001 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/179849 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Qin, Yukun; Li, Pengcheng |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China |
第一作者单位 | 中国科学院海洋研究所 |
通讯作者单位 | 中国科学院海洋研究所 |
推荐引用方式 GB/T 7714 | Gao, Kun,Qin, Yukun,Wang, Linsong,et al. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022:16. |
APA | Gao, Kun.,Qin, Yukun.,Wang, Linsong.,Li, Xin.,Liu, Song.,...&Li, Pengcheng.(2022).Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,16. |
MLA | Gao, Kun,et al."Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022):16. |
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