Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice

doi:10.1016/j.jff.2022.105119

IOCAS-IR > 实验海洋生物学重点实验室

	Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice
	Deng, Zhenzhen 1,2,3,4; Wang, Jing1,2,4 ; Wu, Ning 1,2,4; Geng, Lihua 1,2,4; Zhang, Quanbin 1,2,3,4; Yue, Yang1,2,4
	2022-07-01
发表期刊	JOURNAL OF FUNCTIONAL FOODS
ISSN	1756-4646
卷号	94 页码:9
通讯作者	Yue, Yang(yueyang@qdio.ac.cn)
摘要	Metabolic syndrome (MetS) is a pathological condition characterized by multiple metabolic abnormalities. With the global epidemic of obesity and diabetes, MetS needs more urgent treatments and interventions. Fucoxanthin (FX) and fucoidan are two important active components derived from brown algae, which have been recommended as adjunctive therapy for MetS. In this study, we found that FX and low molecular weight fucoidan fraction LF2 improved insulin resistance (IR) and enhanced insulin sensitivity in high fat diet (HFD)-induced MetS mice synergistically. LF2 and FX could ameliorate HFD-induced liver injury by reducing liver fat deposition, inflammatory response and oxidative stress. Adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling axis is a key target for LF2 and FX to improve MetS. FX and LF2 reduced adipogenesis and conversion through co-activation of AMPK and reduction of the expression of adipogenic differentiation factors. In addition, FX up-regulated the expression of uncoupling protein (UCP-1) and promoted the body's energy expenditure. However, LF2 did not significantly increase the anti-hyperlipidemic effect of FX. Collectively, this study elucidated the synergistic improvement of MetS by FX and LF2 from a molecular perspective. It also demonstrated the potential of fucoxanthin combined with fucoidan as an anti-MetS functional food.
关键词	Fucoxanthin Fucoidan Metabolic Syndrome AMPK Signaling Axis
DOI	10.1016/j.jff.2022.105119
收录类别	SCI
语种	英语
WOS研究方向	Food Science & Technology ; Nutrition & Dietetics
WOS类目	Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:000807851100001
出版者	ELSEVIER
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179687
专题	实验海洋生物学重点实验室
通讯作者	Yue, Yang
作者单位	1.Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Tech, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Deng, Zhenzhen,Wang, Jing,Wu, Ning,et al. Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice[J]. JOURNAL OF FUNCTIONAL FOODS,2022,94:9.
APA	Deng, Zhenzhen,Wang, Jing,Wu, Ning,Geng, Lihua,Zhang, Quanbin,&Yue, Yang.(2022).Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice.JOURNAL OF FUNCTIONAL FOODS,94,9.
MLA	Deng, Zhenzhen,et al."Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice".JOURNAL OF FUNCTIONAL FOODS 94(2022):9.