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Regulation of the Cell Cycle, Apoptosis, and Proline Accumulation Plays an Important Role in the Stress Response of the Eastern Oyster Crassostrea Virginica
Li, Cui1,2,3; Wang, Haiyan2,3; Guo, Ximing1
2022-06-17
发表期刊FRONTIERS IN MARINE SCIENCE
卷号9页码:12
通讯作者Guo, Ximing(xguo@hsrl.rutgers.edu)
摘要BackgroundUnderstanding how organisms respond and adapt to environmental changes is central to evolutionary biology. As a sessile organism that has adapted to life in estuaries and intertidal zones, the eastern oyster Crassostrea virginica can tolerate wide fluctuations in temperature and salinity and survive for weeks out of water. To understand the molecular mechanisms underlying the remarkable stress tolerance of the eastern oyster, we studied the transcriptomic changes induced by exposure to air and cold stress. Eastern oysters were maintained for 7 days under four conditions, namely, in seawater (normal) at 22 degrees C, in air at 22 degrees C, in seawater at 5 degrees C and in air at 5 degrees C, and then sampled for RNA sequencing. ResultsTranscriptomic analysis revealed that many genes involved in cell cycle progression and DNA replication were downregulated in oysters exposed to air and cold, which indicates that stress inhibits cell division. Exposure to air at 22 degrees C induced a concerted inhibition of apoptosis through the upregulation of expanded inhibitors of apoptosis and the downregulation of caspases. Interactions between TNF and NF-kappa B signalling implied a reduction in the inflammatory response and immune functions. Key genes for proline production, fatty acid synthesis and chromosomal proteins were upregulated during exposure to low temperatures, which suggested that proline accumulation, energy conservation, and epigenetic modification of chromosomes are important for coping with cold stress. The upregulation of melatonin, FMRFamide, and neural acetylcholine receptors indicate the significance of the neurohormonal regulation of homeostasis. ConclusionThese results show that air exposure and cold stress alter the expression of key genes for cell division, apoptosis, proline accumulation, fatty acid metabolism, neurohormonal signalling, and epigenetic modifications, suggesting regulation of these processes plays an important role in the stress response of the eastern oyster and possibly other marine molluscs. This study provides new insights into molecular mechanisms of stress response that are essential for understanding the adaptive potential of marine organisms under climate change.
关键词stress transcriptome cell cycle control apoptosis growth immune function epigenetic modification
DOI10.3389/fmars.2022.921877
收录类别SCI
语种英语
WOS研究方向Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS类目Environmental Sciences ; Marine & Freshwater Biology
WOS记录号WOS:000820049900001
出版者FRONTIERS MEDIA SA
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/179620
专题海洋生物分类与系统演化实验室
通讯作者Guo, Ximing
作者单位1.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08854 USA
2.Chinese Acad Sci, Inst Oceanol, Dept Marine Organism Taxon & Phylogeny, Qingdao, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
第一作者单位中国科学院海洋研究所
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Li, Cui,Wang, Haiyan,Guo, Ximing. Regulation of the Cell Cycle, Apoptosis, and Proline Accumulation Plays an Important Role in the Stress Response of the Eastern Oyster Crassostrea Virginica[J]. FRONTIERS IN MARINE SCIENCE,2022,9:12.
APA Li, Cui,Wang, Haiyan,&Guo, Ximing.(2022).Regulation of the Cell Cycle, Apoptosis, and Proline Accumulation Plays an Important Role in the Stress Response of the Eastern Oyster Crassostrea Virginica.FRONTIERS IN MARINE SCIENCE,9,12.
MLA Li, Cui,et al."Regulation of the Cell Cycle, Apoptosis, and Proline Accumulation Plays an Important Role in the Stress Response of the Eastern Oyster Crassostrea Virginica".FRONTIERS IN MARINE SCIENCE 9(2022):12.
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