Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis | |
Zhao, Yan1,2,3 ; Sun, Li1,2,3,4
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| 2022-07-04 | |
| Source Publication | CELL DEATH DISCOVERY
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| Volume | 8Issue:1Pages:8 |
| Corresponding Author | Sun, Li(lsun@qdio.ac.cn) |
| Abstract | Bacillus cereus is well known as a causative agent of foodborne gastrointestinal diseases and systemic non-gastrointestinal diseases. We have recently identified a pathogenic B. cereus (named H2) from a deep-sea cold-seep. H2 possesses the pyroptosis-inducing capacity and contains a number of enterotoxins including cytotoxin K (CytK). In the present work, we examined the cytotoxicity of the CytK of H2 to human macrophages. CytK bound macrophages by interaction with the plasma membrane and caused cellular structure damage. CytK-cell interaction triggered rapid pyroptosis mediated by caspase 1-activated gasdermin D (GSDMD). CytK-induced pyroptosis required NLRP3 inflammasome activation, K+ efflux, and intracellular Ca2+ accumulation. CytK exhibited apparent binding to several cytomembrane lipids, in particular phosphatidic acid, which proved to be essential to CytK-elicited cell death. Together, these results add new insights into the cytotoxic mechanism of CytK. |
| DOI | 10.1038/s41420-022-01091-5 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050403] ; CAS Key Laboratory of Molecular Virology Immunology[KLMVI-OP-202002] ; Taishan Scholar Program of Shandong Province ; Institut Pasteur of Shanghai ; Chinese Academy of Sciences |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| WOS ID | WOS:000820647400001 |
| Publisher | SPRINGERNATURE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/179614 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Sun, Li |
| Affiliation | 1.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, CAS, Qingdao, Peoples R China 2.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China |
| First Author Affilication | Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Corresponding Author Affilication | Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Zhao, Yan,Sun, Li. Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis[J]. CELL DEATH DISCOVERY,2022,8(1):8. |
| APA | Zhao, Yan,&Sun, Li.(2022).Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis.CELL DEATH DISCOVERY,8(1),8. |
| MLA | Zhao, Yan,et al."Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis".CELL DEATH DISCOVERY 8.1(2022):8. |
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