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Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis
Zhao, Yan1,2,3; Sun, Li1,2,3,4
2022-07-04
发表期刊CELL DEATH DISCOVERY
卷号8期号:1页码:8
通讯作者Sun, Li(lsun@qdio.ac.cn)
摘要Bacillus cereus is well known as a causative agent of foodborne gastrointestinal diseases and systemic non-gastrointestinal diseases. We have recently identified a pathogenic B. cereus (named H2) from a deep-sea cold-seep. H2 possesses the pyroptosis-inducing capacity and contains a number of enterotoxins including cytotoxin K (CytK). In the present work, we examined the cytotoxicity of the CytK of H2 to human macrophages. CytK bound macrophages by interaction with the plasma membrane and caused cellular structure damage. CytK-cell interaction triggered rapid pyroptosis mediated by caspase 1-activated gasdermin D (GSDMD). CytK-induced pyroptosis required NLRP3 inflammasome activation, K+ efflux, and intracellular Ca2+ accumulation. CytK exhibited apparent binding to several cytomembrane lipids, in particular phosphatidic acid, which proved to be essential to CytK-elicited cell death. Together, these results add new insights into the cytotoxic mechanism of CytK.
DOI10.1038/s41420-022-01091-5
收录类别SCI
语种英语
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050403] ; CAS Key Laboratory of Molecular Virology Immunology[KLMVI-OP-202002] ; Taishan Scholar Program of Shandong Province ; Institut Pasteur of Shanghai ; Chinese Academy of Sciences
WOS研究方向Cell Biology
WOS类目Cell Biology
WOS记录号WOS:000820647400001
出版者SPRINGERNATURE
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/179614
专题实验海洋生物学重点实验室
通讯作者Sun, Li
作者单位1.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, CAS, Qingdao, Peoples R China
2.Chinese Acad Sci, CAS Ctr Ocean Megasci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China
第一作者单位中国科学院海洋大科学研究中心
通讯作者单位中国科学院海洋大科学研究中心
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Zhao, Yan,Sun, Li. Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis[J]. CELL DEATH DISCOVERY,2022,8(1):8.
APA Zhao, Yan,&Sun, Li.(2022).Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis.CELL DEATH DISCOVERY,8(1),8.
MLA Zhao, Yan,et al."Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis".CELL DEATH DISCOVERY 8.1(2022):8.
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