Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter

doi:10.1038/s42003-022-03587-3

IOCAS-IR > 实验海洋生物学重点实验室

	Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter
	Li, Mofei1,2,3 ; Wu, Meng 1,2,4,5; Sun, Yuanyuan1,2,4 ; Sun, Li 1,2,4,5
	2022-06-29
发表期刊	COMMUNICATIONS BIOLOGY
卷号	5 期号:1 页码:13
通讯作者	Sun, Li(lsun@qdio.ac.cn)
摘要	Edwardsiella tarda TraT promotes cellular infection and serves as an anti-complement factor, shedding light on the mechanisms of E. tarda's strong evasion of killing by the host. Edwardsiella tarda is a well-known bacterial pathogen with a broad range of host, including fish, amphibians, and mammals. One eminent virulence feature of E. tarda is its strong ability to resist the killing of host serum complement, but the involving mechanism is unclear. In this report, we identified E. tarda TraT as a key player in both complement resistance and cellular invasion. TraT, a surface-localized protein, bound and recruited complement factor H onto E. tarda, whereby inhibiting complement activation via the alternative pathway. TraT also interacted with host CD46 in a specific complement control protein domain-dependent manner, whereby facilitating the cellular infection and tissue dissemination of E. tarda. Thus, by acting as an anti-complement factor and a cellular infection promoter, TraT makes an important contribution to the complement evasion and systemic infection of E. tarda. These results add insights into the pathogen-host interaction mechanism during E. tarda infection.
DOI	10.1038/s42003-022-03587-3
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFD0900500] ; National Natural Science Foundation of China[31972831] ; National Natural Science Foundation of China[41906108] ; Young Scholar Program of Tianjin Distinguished Professor ; Taishan Scholar Program of Shandong Province
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
WOS类目	Biology ; Multidisciplinary Sciences
WOS记录号	WOS:000820414000008
出版者	NATURE PORTFOLIO
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179596
专题	实验海洋生物学重点实验室
通讯作者	Sun, Li
作者单位	1.Chinese Acad Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Tianjin Normal Univ, Coll Life Sci, Tianjin Key Lab Anim & Plant Resistance, 393 West Binshui Rd, Tianjin 300387, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Li, Mofei,Wu, Meng,Sun, Yuanyuan,et al. Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter[J]. COMMUNICATIONS BIOLOGY,2022,5(1):13.
APA	Li, Mofei,Wu, Meng,Sun, Yuanyuan,&Sun, Li.(2022).Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter.COMMUNICATIONS BIOLOGY,5(1),13.
MLA	Li, Mofei,et al."Edwardsiella tarda TraT is an anti-complement factor and a cellular infection promoter".COMMUNICATIONS BIOLOGY 5.1(2022):13.