Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia

doi:10.3389/fmars.2022.898669

	Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia
	Hu, Zhi 1,2,3,4,5,6; Song, Hao 1,2,3,4,6; Feng, Jie 1,2,3,4,6; Zhou, Cong1,2,3,4,5,6 ; Yang, Mei-Jie 1,2,3,4,6; Shi, Pu1,2,3,4,5,6 ; Yu, Zheng-Lin 7; Li, Yong-Ren 8; Guo, Yong-Jun 8; Li, Hai-Zhou 9; Zhang, Tao1,2,3,4,6
	2022-05-27
发表期刊	FRONTIERS IN MARINE SCIENCE
卷号	9 页码:14
通讯作者	Zhang, Tao(tzhang@qdio.ac.cn)
摘要	Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods including Blastp, HMM and manual filtration, based on the whole Mercenaria mercenaria genome. The MmHSP70 genes were unevenly distributed, and 41 genes (33.08%) were located on Chr 7. Phylogenetic analyses indicated that the MmHSP70 gene family mainly consisted of two clusters and the Hspa12 subfamily underwent lineage-specific expansion. A high-density collinear gene block was observed between M. mercenaria Chr 7 and Cyclina sinensis Chr 14. Tandem duplication MmHSP70 gene pairs experienced different levels of purifying selection, which could be an important source of sequence and functional constraints. MmHSP70 genes showed tissue-specific and stress-specific expression. Most tandem duplication HSP70 gene pairs had high expression under hypoxia stress. HSP70 B2 tandem duplication gene pairs showed significantly increased expression under heat plus severe hypoxia stress. This study provided a comprehensive understanding of the MmHSP70 gene family in the M. mercenaria and laid a significant foundation for further studies on the functional characteristics of MmHSP70 genes during exposure to heat and hypoxia stress.
关键词	Mercenaria mercenaria HSP70 heat hypoxia adaptation
DOI	10.3389/fmars.2022.898669
收录类别	SCI
语种	英语
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology
WOS类目	Environmental Sciences ; Marine & Freshwater Biology
WOS记录号	WOS:000810171900001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179549
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang, Tao
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 7.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 8.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin, Peoples R China 9.Shandong Fu Han Ocean Scitech Co Ltd, Haiyang, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Hu, Zhi,Song, Hao,Feng, Jie,et al. Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia[J]. FRONTIERS IN MARINE SCIENCE,2022,9:14.
APA	Hu, Zhi.,Song, Hao.,Feng, Jie.,Zhou, Cong.,Yang, Mei-Jie.,...&Zhang, Tao.(2022).Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia.FRONTIERS IN MARINE SCIENCE,9,14.
MLA	Hu, Zhi,et al."Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia".FRONTIERS IN MARINE SCIENCE 9(2022):14.

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