Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence

doi:10.3389/fnut.2022.876992

IOCAS-IR > 实验海洋生物学重点实验室

	Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence
	Wang, Xiaomei 1; Xu, Xiaogang 2,3; Mao, Genxiang 2,3; Guo, Yue 1; Wang, Guangce 4,5; Sun, Xue 6; Xu, Nianjun 6; Zhang, Zhongshan 1
	2022-05-16
发表期刊	FRONTIERS IN NUTRITION
ISSN	2296-861X
卷号	9 页码:12
通讯作者	Mao, Genxiang(maogenxiang@163.com) ; Xu, Nianjun(xunianjun@nbu.edu.cn) ; Zhang, Zhongshan(01959@zjhu.edu.cn)
摘要	The sulfated polysaccharide was isolated from the purified G. lemaneiformis polysaccharide (PGP), and its property in delaying H2O2-induced 2BS cellular senescence was studied. The results showed that PGP was a linear polysaccharide containing alternating alpha-(1 -> 3)-and beta-(1 -> 4)-galactopyranose units. Most of the sulfate groups are at C6 of the-(1 -> 4)-alpha-D-Galp, and a small part of them are at C3 and C6. PGP pretreatment could decrease SA-beta-gal-positive cells and prevent the formation of senescence-associated heterochromatic foci (SAHF) induced by H2O2 in a dose-dependent manner. It is speculated that PGP may delay aging by downregulating the expression of p21 and p53 genes. The finding provides new insights into the beneficial role of G. lemaneiformis polysaccharide (GP) on retarding senescence process.
关键词	G. lemaneiformis polysaccharide cellular senescence SA-beta-gal p53-p21 pathway
DOI	10.3389/fnut.2022.876992
收录类别	SCI
语种	英语
资助项目	Zhejiang Province Basic public welfare research project[LGN21D060001] ; National Natural Science Foundation of China[31700307] ; National Natural Science Foundation of China[81771520]
WOS研究方向	Nutrition & Dietetics
WOS类目	Nutrition & Dietetics
WOS记录号	WOS:000804429200001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179465
专题	实验海洋生物学重点实验室
通讯作者	Mao, Genxiang; Xu, Nianjun; Zhang, Zhongshan
作者单位	1.Huzhou Univ, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China 2.Zhejiang Hosp, Key Labof Geriatr, Dept Geriatr, Hangzhou, Peoples R China 3.Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Dept Geriatr, Hangzhou, Peoples R China 4.Chinese Acad Sci, Qingdao, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 6.Ningbo Univ, Collaborat Innovat Ctr Zhejiang Marine High Effici, Natl Engn Res Lab Marine Biotechnol & Engn, Key Lab Aquacultural Biotechnol,Minist Educ,Key La, Ningbo, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xiaomei,Xu, Xiaogang,Mao, Genxiang,et al. Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence[J]. FRONTIERS IN NUTRITION,2022,9:12.
APA	Wang, Xiaomei.,Xu, Xiaogang.,Mao, Genxiang.,Guo, Yue.,Wang, Guangce.,...&Zhang, Zhongshan.(2022).Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence.FRONTIERS IN NUTRITION,9,12.
MLA	Wang, Xiaomei,et al."Structural Characterization of Gracilariopsis lemaneiformis Polysaccharide and Its Property in Delaying Cellular Senescence".FRONTIERS IN NUTRITION 9(2022):12.

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