Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom | |
Li, Aoyu1,2,3; Yu, Huahua1,2 ; Li, Rongfeng1,2; Yue, Yang1,2; Yu, Chunlin1,2,3; Geng, Hao1,2,3; Liu, Song1,2; Xing, Ronge1,2; Li, Pengcheng1,2
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| 2022-07-01 | |
| Source Publication | BIOMEDICINE & PHARMACOTHERAPY
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| ISSN | 0753-3322 |
| Volume | 151Pages:8 |
| Corresponding Author | Yu, Huahua(yuhuahua@qdio.ac.cn) |
| Abstract | Jellyfish envenomation is a common medical problem in many countries. However, the myotoxicity and effector molecules of scyphozoan venoms remain uninvestigated. Here, we present the myotoxicity of nematocyst venom from Nemopilema nomurai (NnNV), a giant venomous scyphozoan from China, for the first time, using in vivo models with inhibitors. NnNV was able to induce remarkable myotoxicity including significant muscle swelling, increasing the content of CK and LDH in serum, stimulating inflammation of muscle tissue, and destroying the structure of muscle tissue. In addition, the metalloproteinase inhibitors BMT and EDTA significantly reduced the myotoxicity induced by NnNV. Moreover, BMT and EDTA could decrease the inflammatory stimulation and necrosis of muscle tissue caused by the venom. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to myotoxicity. This study contributes to understanding the effector molecules of muscle injury caused by jellyfish stings and suggests a new idea for the treatment of scyphozoan envenomation. |
| Keyword | Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Myotoxicity Metalloprotease |
| DOI | 10.1016/j.biopha.2022.113192 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key R&D Program of China[2017YFE0111100-04] ; National Key R&D Program of China[2019YFC0312605] ; National Natural Sci-ence Foundation of China[41776163] ; National Natural Sci-ence Foundation of China[41876164] ; Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220] ; Natural Science Foundation of Shandong Province[ZR2019QD012] |
| WOS Research Area | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS Subject | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| WOS ID | WOS:000807392900004 |
| Publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/179435 |
| Collection | 实验海洋生物学重点实验室 |
| Corresponding Author | Yu, Huahua |
| Affiliation | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,151:8. |
| APA | Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2022).Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom.BIOMEDICINE & PHARMACOTHERAPY,151,8. |
| MLA | Li, Aoyu,et al."Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom".BIOMEDICINE & PHARMACOTHERAPY 151(2022):8. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S075333222200（4817KB） | 期刊论文 | 出版稿 | 延迟开放 | CC BY-NC-SA | View 2023-7-1后可获取 | |
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