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Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom
Li, Aoyu1,2,3; Yu, Huahua1,2; Li, Rongfeng1,2; Yue, Yang1,2; Yu, Chunlin1,2,3; Geng, Hao1,2,3; Liu, Song1,2; Xing, Ronge1,2; Li, Pengcheng1,2
2022-07-01
发表期刊BIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
卷号151页码:8
通讯作者Yu, Huahua(yuhuahua@qdio.ac.cn)
摘要Jellyfish envenomation is a common medical problem in many countries. However, the myotoxicity and effector molecules of scyphozoan venoms remain uninvestigated. Here, we present the myotoxicity of nematocyst venom from Nemopilema nomurai (NnNV), a giant venomous scyphozoan from China, for the first time, using in vivo models with inhibitors. NnNV was able to induce remarkable myotoxicity including significant muscle swelling, increasing the content of CK and LDH in serum, stimulating inflammation of muscle tissue, and destroying the structure of muscle tissue. In addition, the metalloproteinase inhibitors BMT and EDTA significantly reduced the myotoxicity induced by NnNV. Moreover, BMT and EDTA could decrease the inflammatory stimulation and necrosis of muscle tissue caused by the venom. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to myotoxicity. This study contributes to understanding the effector molecules of muscle injury caused by jellyfish stings and suggests a new idea for the treatment of scyphozoan envenomation.
关键词Jellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Myotoxicity Metalloprotease
DOI10.1016/j.biopha.2022.113192
收录类别SCI
语种英语
资助项目National Key R&D Program of China[2017YFE0111100-04] ; National Key R&D Program of China[2019YFC0312605] ; National Natural Sci-ence Foundation of China[41776163] ; National Natural Sci-ence Foundation of China[41876164] ; Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220] ; Natural Science Foundation of Shandong Province[ZR2019QD012]
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS记录号WOS:000807392900004
出版者ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/179435
专题实验海洋生物学重点实验室
通讯作者Yu, Huahua
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
通讯作者单位中国科学院海洋研究所
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Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,151:8.
APA Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2022).Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom.BIOMEDICINE & PHARMACOTHERAPY,151,8.
MLA Li, Aoyu,et al."Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom".BIOMEDICINE & PHARMACOTHERAPY 151(2022):8.
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