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Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom
Li, Aoyu1,2,3; Yu, Huahua1,2; Li, Rongfeng1,2; Yue, Yang1,2; Yu, Chunlin1,2,3; Geng, Hao1,2,3; Liu, Song1,2; Xing, Ronge1,2; Li, Pengcheng1,2
2022-07-01
Source PublicationBIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
Volume151Pages:8
Corresponding AuthorYu, Huahua(yuhuahua@qdio.ac.cn)
AbstractJellyfish envenomation is a common medical problem in many countries. However, the myotoxicity and effector molecules of scyphozoan venoms remain uninvestigated. Here, we present the myotoxicity of nematocyst venom from Nemopilema nomurai (NnNV), a giant venomous scyphozoan from China, for the first time, using in vivo models with inhibitors. NnNV was able to induce remarkable myotoxicity including significant muscle swelling, increasing the content of CK and LDH in serum, stimulating inflammation of muscle tissue, and destroying the structure of muscle tissue. In addition, the metalloproteinase inhibitors BMT and EDTA significantly reduced the myotoxicity induced by NnNV. Moreover, BMT and EDTA could decrease the inflammatory stimulation and necrosis of muscle tissue caused by the venom. These observations suggest that the metalloproteinase components of NnNV make a considerable contribution to myotoxicity. This study contributes to understanding the effector molecules of muscle injury caused by jellyfish stings and suggests a new idea for the treatment of scyphozoan envenomation.
KeywordJellyfish envenomation Nemopilema nomurai nematocyst venom (NnNV) Myotoxicity Metalloprotease
DOI10.1016/j.biopha.2022.113192
Indexed BySCI
Language英语
Funding ProjectNational Key R&D Program of China[2017YFE0111100-04] ; National Key R&D Program of China[2019YFC0312605] ; National Natural Sci-ence Foundation of China[41776163] ; National Natural Sci-ence Foundation of China[41876164] ; Major Projects on the Transformation of Old and Novel Kinetic Energy of Shandong Province[2020-1220] ; Natural Science Foundation of Shandong Province[ZR2019QD012]
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000807392900004
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/179435
Collection实验海洋生物学重点实验室
Corresponding AuthorYu, Huahua
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Li, Aoyu,Yu, Huahua,Li, Rongfeng,et al. Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,151:8.
APA Li, Aoyu.,Yu, Huahua.,Li, Rongfeng.,Yue, Yang.,Yu, Chunlin.,...&Li, Pengcheng.(2022).Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom.BIOMEDICINE & PHARMACOTHERAPY,151,8.
MLA Li, Aoyu,et al."Jellyfish Nemopilema nomurai causes myotoxicity through the metalloprotease component of venom".BIOMEDICINE & PHARMACOTHERAPY 151(2022):8.
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