Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252

doi:10.3390/ijms23105567

IOCAS-IR > 实验海洋生物学重点实验室

	Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252
	Li, Yanhe1,2,3 ; Li, Xiaoming 1,2; Li, Xin1,2 ; Yang, Suiqun1,2 ; Wang, Bingui1,2,3,4 ; Li, Honglei1,2
	2022-05-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	23 期号:10 页码:11
通讯作者	Wang, Bingui(wangbg@ms.qdio.ac.cn) ; Li, Honglei(lihonglei@qdio.ac.cn)
摘要	Six novel verrucosidin derivatives, namely, poloncosidins A-F (1-6), together with one known analogue (7), were isolated and identified from the deep-sea-derived fungus Penicillium polonicum CS-252, which was obtained from cold-seep sediments collected in the South China Sea at a depth of 1183 m. Their structures were mainly established on the basis of a detailed interpretation of NMR spectroscopic and mass spectrometric data. The relative and absolute configurations of compounds 1-6 were determined by ECD calculations and a DP4+ probability analysis. Compounds 1-5 represent the first examples of verrucosidins with a 2,5-dihydrofuran ring which is uncommon among the known analogues. These compounds exhibited inhibitory activities against several human and aquatic pathogens with MIC values ranging from 4 to 32 mu g/mL.
关键词	deep-sea-derived fungus Penicillium polonicum verrucosidin derivatives structure elucidation antimicrobial activity
DOI	10.3390/ijms23105567
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42076090] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; Senior User Project of RV KEXUE[KEXUE2020GZ02]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000801608100001
出版者	MDPI
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/179312
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bingui; Li, Honglei
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Li, Yanhe,Li, Xiaoming,Li, Xin,et al. Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(10):11.
APA	Li, Yanhe,Li, Xiaoming,Li, Xin,Yang, Suiqun,Wang, Bingui,&Li, Honglei.(2022).Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(10),11.
MLA	Li, Yanhe,et al."Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.10(2022):11.

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