Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br | |
Wang, Linsong1,2,3; Qin, Yukun1,2,3; Fan, Zhaoqian1,2,3; Gao, Kun1,2,3; Zhan, Jiang1,2,3,4; Xing, Ronge1,2,3; Liu, Song1,2,3; Li, Pengcheng1,2,3 | |
2022-04-20 | |
发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY |
ISSN | 0021-8561 |
卷号 | 70期号:15页码:4644-4657 |
通讯作者 | Qin, Yukun(ykqin@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn) |
摘要 | :to replace biohazardous nematicides, there is an ever-increasing need to identify natural product-based agents tocontain root-knot nematodes (RKNs) in agriculture. In this chemical ecology study, an antagonistic fungusAspergillus fumigatus1T-2, which could cause the formation of withering of the gut and vacuole-like structures in the nematode body, was isolated based onthe gradually increased antagonistic interactions between the soil fungi and RKNs. Based on these typical morphologicalcharacteristics, a potent nematode-antagonistic compound 2-furoic acid, which had a simple structure, was successfully identifiedfrom 1T-2 fermentation broth by liquid chromatography-mass spectrometry (LC-MS). 2-Furoic acid showed effective mortalityactivityin vitro, of which the LC50value toMegalaima incognitaat 24 h was 37.75 mu g/mL. 2-Furoic acid had similar mortality activityto the positive control fosthiazate at 30 mu g/mL. Continuous 2-furoic acid exposure had obvious negative influences on bothnematode vitality and egg hatchability. Notably, significant variations were observed in nematodes and eggs with 2-furoic acidtreatment, which might be induced by novel nematocidal mechanisms. Furthermore, the 1T-2 fermentation broth and 2-furoic acidhad significant control efficacy onM. incognitaunder the greenhouse test-tube assay. Overall, thesefindings provide valuable insightsinto the use of 2-furoic acid with biocontrol potential as a preferable lead structure for the development of innovative nematicides |
关键词 | Meloidogyne incognita chemical ecology Aspergillus fumigatus 1T-2 2-furoic acid biocontrol |
DOI | 10.1021/acs.jafc.1c08147 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key R&D Program of China[2019YFD0900705] ; National Natural Science Foundation of China[42076126] ; Shandong Provincial Natural Science Foundation[ZR2020MD072] ; Shandong Provincial Natural Science Foundation Youth Fund[ZR2021QC006] ; Qingdao Science and Technology Demonstration and Guidance Project[20-3-4-22-nsh] |
WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
WOS类目 | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
WOS记录号 | WOS:000794068900014 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/179291 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Qin, Yukun; Li, Pengcheng |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, CAS, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
第一作者单位 | 中国科学院海洋大科学研究中心 |
通讯作者单位 | 中国科学院海洋大科学研究中心 |
推荐引用方式 GB/T 7714 | Wang, Linsong,Qin, Yukun,Fan, Zhaoqian,et al. Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(15):4644-4657. |
APA | Wang, Linsong.,Qin, Yukun.,Fan, Zhaoqian.,Gao, Kun.,Zhan, Jiang.,...&Li, Pengcheng.(2022).Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(15),4644-4657. |
MLA | Wang, Linsong,et al."Novel Lead Compound Discovery from Aspergillus fumigatus 1T-2against Meloidogyne incognita Based on a Chemical Ecology Study br".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.15(2022):4644-4657. |
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