<p>In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles</p>

doi:10.1016/j.cplett.2022.139360

	In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles
	Li, Zhen 1; Wei, Qi 1; Qi, Ziqiang 1; Zhou, Lixia 3; Li, Jiawei 1,2
	2022-03-01
发表期刊	CHEMICAL PHYSICS LETTERS
ISSN	0009-2614
卷号	790 页码:7
通讯作者	Li, Jiawei(xiicarson@gmail.com)
摘要	To provide insights into the receptor-mediated endocytosis of virus-like nanoparticles (VLPs), we carried out a series of in silico dissipative particle dynamics (DPD) simulations on the interaction of lipid membrane and VLPs with varying spike length and spike number. Of great interest is that the VLP endocytosis is facilitated by short spikes but hindered by long spikes, showing a "biphasic effect ". With scrutinizing the endocytosis pathway and dynamic behavior of receptors, we clarified molecular mechanisms underlying the biphasic effect. These results demonstrate the importance of nanotopography on cellular internalization, which could inspire future manipulation of VLPs for biomedical applications.
关键词	Dissipative particle dynamics Bio-nano interaction Membrane remodeling Transmembrane transport Nanoparticle surface topology
DOI	10.1016/j.cplett.2022.139360
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFA0702400] ; National Natural Science Foundation of China[12004438] ; Natural Science Foundation of Shandong Province[ZR2020QB078] ; Fundamental Research Funds for the Central Universities[20CX06011A]
WOS研究方向	Chemistry ; Physics
WOS类目	Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
WOS记录号	WOS:000788810500001
出版者	ELSEVIER
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178961
专题	海洋环境腐蚀与生物污损重点实验室
通讯作者	Li, Jiawei
作者单位	1.China Univ Petr East China, Sch Mat Sci & Engn, Qingdao 266580, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.China Univ Petr East China, Coll Sci, Qingdao 266580, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Zhen,Wei, Qi,Qi, Ziqiang,et al. In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles [J]. CHEMICAL PHYSICS LETTERS,2022,790:7.
APA	Li, Zhen,Wei, Qi,Qi, Ziqiang,Zhou, Lixia,&Li, Jiawei.(2022). In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles .CHEMICAL PHYSICS LETTERS,790,7.
MLA	Li, Zhen,et al." In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles ".CHEMICAL PHYSICS LETTERS 790(2022):7.

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