Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation

doi:10.3390/jmse10030428

IOCAS-IR > 实验海洋生物学重点实验室

	Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation
	Cao, Xuwen1,2,3,4,5 ; Sun, Peiqi1,2,3,4,5 ; Zhang, Liusuo 1,2,3,4
	2022-03-01
发表期刊	JOURNAL OF MARINE SCIENCE AND ENGINEERING
卷号	10 期号:3 页码:17
通讯作者	Zhang, Liusuo(lzhang@qdio.ac.cn)
摘要	Stearic acid represents one of the most abundant fatty acids in the Western diet and profoundly regulates health and diseases of animals and human beings. We previously showed that stearic acid supplementation promoted development of the terrestrial model nematode Caenorhabditis elegans in chemically defined CeMM food environment. However, whether stearic acid regulates development of other nematodes remains unknown. Here, we found that dietary supplementation with stearic acid could promote the development of the marine nematode Litoditis marina, belonging to the same family as C. elegans, indicating the conserved roles of stearic acid in developmental regulation. We further employed transcriptome analysis to analyze genome-wide transcriptional signatures of L. marina with dietary stearic acid supplementation. We found that stearic acid might promote development of L. marina via upregulation of the expression of genes involved in aminoacyl-tRNA biosynthesis, translation initiation and elongation, ribosome biogenesis, and transmembrane transport. In addition, we observed that the expression of neuronal signaling-related genes was decreased. This study provided important insights into how a single fatty acid stearic acid regulates development of marine nematode, and further studies with CRISPR genome editing will facilitate demonstrating the molecular mechanisms underlying how a single metabolite regulates animal development and health.
关键词	marine nematode stearic acid CeMM development transcriptome protein translation neuronal signaling
DOI	10.3390/jmse10030428
收录类别	SCI
语种	英语
资助项目	National Key R and D Program of China[2018YFD0901301] ; Talents from overseas Program, IOCAS of the Chinese Academy of Sciences ; Qingdao Innovation Leadership Program[16-8-3-19-zhc] ; Key deployment project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q16]
WOS研究方向	Engineering ; Oceanography
WOS类目	Engineering, Marine ; Engineering, Ocean ; Oceanography
WOS记录号	WOS:000774852900001
出版者	MDPI
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178643
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Liusuo
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Cao, Xuwen,Sun, Peiqi,Zhang, Liusuo. Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation[J]. JOURNAL OF MARINE SCIENCE AND ENGINEERING,2022,10(3):17.
APA	Cao, Xuwen,Sun, Peiqi,&Zhang, Liusuo.(2022).Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation.JOURNAL OF MARINE SCIENCE AND ENGINEERING,10(3),17.
MLA	Cao, Xuwen,et al."Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation".JOURNAL OF MARINE SCIENCE AND ENGINEERING 10.3(2022):17.

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