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Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach
Hu, Zhi1,2,3,4,5; Feng, Jie1,2,3,4; Song, Hao1,2,3,4; Zhou, Cong1,2,3,4,5; Yang, Mei-Jie1,2,3,4; Shi, Pu1,2,3,4,5; Yu, Zheng-Lin6; Guo, Yong-Jun7; Li, Yong-Ren7; Zhang, Tao1,2,3,4
2022-02-25
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume809Pages:12
Corresponding AuthorZhang, Tao(tzhang@qdio.ac.cn)
AbstractIn the context of global climatic changes, marine organisms have been exposed to environmental stressors including heat and hypoxia. This calls for the design of multi-stressors to uncover the impact of oceanic factors on aquatic organisms. So far, little is known about the metabolic response of marine organisms, especially bivalves, to the combined effects of heat and hypoxia. In this study, we employed widely targeted metabolomic analysis to study the metabolic response of gills in hard clam, a heat- and hypoxia-tolerant bivalve. A total of 810 metabolites were identified. Results showed that the heat group (HT) and heat plus hypoxia group (HL) had a higher number of differential metabolites than the hypoxia group (LO). Glycolysis was affected by the heat and heat plus hypoxia stress. Moreover, anaerobic metabolic biomarkers were accumulated marking the onset of anaerobic metabolism. Environmental stresses may affect Tricarboxylic acid (TCA) cycle. Accumulation of carnitine and glycerophospholipid may promote fatty acid beta oxidation and maintain cell membrane stability, respectively. The high content of oxidized lipids (i.e., Leukotriene) in HL and HT groups implied that the organisms were under ROS stress. The significantly differential metabolites of organic osmolytes and vitamins might relieve ROS stress. Moreover, accumulation of thermoprotective osmolytes (monosaccharide, Trimethylamine N-oxide (TMAO)) accumulation was helpful to maintain protein homeostasis. This investigation provided new insights into the adaptation mechanisms of hard clam to heat, hypoxia and combined stress at the metabolite level and highlighted the roles of molecules and protectants. (C) 2021 Published by Elsevier B.V.
KeywordMercenaria mercenaria Metabolome Heat Hypoxia Stress
DOI10.1016/j.scitotenv.2021.151172
Indexed BySCI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000755050800005
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/178090
Collection海洋生态与环境科学重点实验室
Corresponding AuthorZhang, Tao
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
7.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin 300384, Peoples R China
First Author AffilicationKey Laboratory of Marine Ecology & Environmental Sciences, CAS;  Center for Ocean Mega-Science, Chinese Academy of Sciences;  Institute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationKey Laboratory of Marine Ecology & Environmental Sciences, CAS;  Center for Ocean Mega-Science, Chinese Academy of Sciences;  Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Zhi,Feng, Jie,Song, Hao,et al. Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,809:12.
APA Hu, Zhi.,Feng, Jie.,Song, Hao.,Zhou, Cong.,Yang, Mei-Jie.,...&Zhang, Tao.(2022).Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach.SCIENCE OF THE TOTAL ENVIRONMENT,809,12.
MLA Hu, Zhi,et al."Metabolic response of Mercenaria mercenaria under heat and hypoxia stress by widely targeted metabolomic approach".SCIENCE OF THE TOTAL ENVIRONMENT 809(2022):12.
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