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Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406
Yan, Li-Hong1,2,3; Li, Xiao-Ming1,2,4; Chi, Lu-Ping1,2,3; Li, Xin1,2,4; Wang, Bin-Gui1,2,3,4
2022
Source PublicationMARINE DRUGS
Volume20Issue:1Pages:14
Corresponding AuthorLi, Xin(lixin@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
AbstractSix new metabolites, including a pair of inseparable mixtures of secofumitremorgins A (1a) and B (1b), which differed in the configuration of the nitrogen atom, 29-hydroxyfumiquinazoline C (6), 10R-15-methylpseurotin A (7), 1,4,23-trihydroxy-hopane-22,30-diol (10), and sphingofungin I (11), together with six known compounds (2-5 and 8-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Their structures were determined by detailed spectroscopic analysis of NMR and MS data, chiral HPLC analysis of the acidic hydrolysate, X-ray crystallographic analysis, J-based configuration analysis, and quantum chemical calculations of ECD, OR, and NMR (with DP4+ probability analysis). Among the compounds, 1a/1b represent a pair of novel scaffolds derived from indole diketopiperazine by cleavage of the amide bond following aromatization to give a pyridine ring. Compounds 1, 4, 6, 7, 10 and 11 showed inhibitory activities against pathogenic bacteria and plant pathogenic fungus, with MIC values ranging from 4 to 64 mu g/mL.
KeywordAspergillus fumigatus deep-sea sediment-derived fungus alkaloids triterpenoid antimicrobial activity
DOI10.3390/md20010004
Indexed BySCI
Language英语
Funding ProjectStrategic Priority Research Program of Chinese Academy of Sciences[XDA22050401] ; National Natural Science Foundation of China[42076090] ; National Natural Science Foundation of China[U2006203] ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000758744500001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/178030
Collection实验海洋生物学重点实验室
Corresponding AuthorLi, Xin; Wang, Bin-Gui
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yan, Li-Hong,Li, Xiao-Ming,Chi, Lu-Ping,et al. Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406[J]. MARINE DRUGS,2022,20(1):14.
APA Yan, Li-Hong,Li, Xiao-Ming,Chi, Lu-Ping,Li, Xin,&Wang, Bin-Gui.(2022).Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406.MARINE DRUGS,20(1),14.
MLA Yan, Li-Hong,et al."Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406".MARINE DRUGS 20.1(2022):14.
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