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Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
Farooqi, Ammad Ahmad1; Tahir, Fatima; Fakhar, Maham2; Butt, Ghazala2; Pimentel, Tatiana Colombo3; Wu, Ning4; Yulaevna, Ishmuratova Margarita5; Attar, Rukset6
2021
发表期刊CELLULAR AND MOLECULAR BIOLOGY
ISSN0145-5680
卷号67期号:2页码:178-186
通讯作者Farooqi, Ammad Ahmad(Farooqiammadahmad@gmail.com) ; Butt, Ghazala(dr.ghazalayasmeen@gcu.edu.pk)
摘要The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/13-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/13-catenin, TGF/ SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis.
关键词Cancer Apoptosis Signaling Xenografted mice
DOI10.14715/cmb/2021.67.2.28
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000744172400028
出版者C M B ASSOC
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/177930
专题实验海洋生物学重点实验室
通讯作者Farooqi, Ammad Ahmad; Butt, Ghazala
作者单位1.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad, Pakistan
2.Govt Coll Univ, Dept Bot, Lahore, Pakistan
3.Fed Inst Parana IFPR, Campus Paranavai, BR-87703536 Paranaque, Brazil
4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
5.EA Buketov Karaganda Univ, Karaganda, Kazakhstan
6.Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkey
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Farooqi, Ammad Ahmad,Tahir, Fatima,Fakhar, Maham,et al. Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights[J]. CELLULAR AND MOLECULAR BIOLOGY,2021,67(2):178-186.
APA Farooqi, Ammad Ahmad.,Tahir, Fatima.,Fakhar, Maham.,Butt, Ghazala.,Pimentel, Tatiana Colombo.,...&Attar, Rukset.(2021).Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights.CELLULAR AND MOLECULAR BIOLOGY,67(2),178-186.
MLA Farooqi, Ammad Ahmad,et al."Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights".CELLULAR AND MOLECULAR BIOLOGY 67.2(2021):178-186.
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