Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights | |
Farooqi, Ammad Ahmad1; Tahir, Fatima; Fakhar, Maham2; Butt, Ghazala2; Pimentel, Tatiana Colombo3; Wu, Ning4; Yulaevna, Ishmuratova Margarita5; Attar, Rukset6 | |
2021 | |
发表期刊 | CELLULAR AND MOLECULAR BIOLOGY |
ISSN | 0145-5680 |
卷号 | 67期号:2页码:178-186 |
通讯作者 | Farooqi, Ammad Ahmad(Farooqiammadahmad@gmail.com) ; Butt, Ghazala(dr.ghazalayasmeen@gcu.edu.pk) |
摘要 | The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/13-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/13-catenin, TGF/ SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis. |
关键词 | Cancer Apoptosis Signaling Xenografted mice |
DOI | 10.14715/cmb/2021.67.2.28 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000744172400028 |
出版者 | C M B ASSOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/177930 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Farooqi, Ammad Ahmad; Butt, Ghazala |
作者单位 | 1.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad, Pakistan 2.Govt Coll Univ, Dept Bot, Lahore, Pakistan 3.Fed Inst Parana IFPR, Campus Paranavai, BR-87703536 Paranaque, Brazil 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.EA Buketov Karaganda Univ, Karaganda, Kazakhstan 6.Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkey |
推荐引用方式 GB/T 7714 | Farooqi, Ammad Ahmad,Tahir, Fatima,Fakhar, Maham,et al. Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights[J]. CELLULAR AND MOLECULAR BIOLOGY,2021,67(2):178-186. |
APA | Farooqi, Ammad Ahmad.,Tahir, Fatima.,Fakhar, Maham.,Butt, Ghazala.,Pimentel, Tatiana Colombo.,...&Attar, Rukset.(2021).Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights.CELLULAR AND MOLECULAR BIOLOGY,67(2),178-186. |
MLA | Farooqi, Ammad Ahmad,et al."Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights".CELLULAR AND MOLECULAR BIOLOGY 67.2(2021):178-186. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论