IOCAS-IR  > 实验海洋生物学重点实验室
Low molecular weight fucoidan fraction LF2 improves metabolic syndrome via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of Akkermansia muciniphila in the gut microbiota
Deng, Zhenzhen1,2,3; Wu, Ning1,2; Wang, Jing1,2; Geng, Lihua1,2; Yue, Yang1,2; Wang, Fahe4; Zhang, Quanbin1,2,3
2021-12-15
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume193Pages:789-798
Corresponding AuthorZhang, Quanbin(qbzhang@qdio.ac.cn)
AbstractMetabolic syndrome (MetS) is a pathological condition of a variety of metabolic abnormalities, which requires more urgent treatment and intervention. Fucoidan has been recommended as a supplement for health enhancement and disease management. Here, we first propose that the beneficial effect of low molecular weight fucoidan fraction LF2 in regulating metabolic syndrome induced by high-fat diet is similar to that of metformin, in terms of molecular mechanism and gut microbiota. The study found that LF2 significantly reduces fasting blood glucose, enhances insulin sensitivity and restores insulin homeostasis and lipid homeostasis. Moreover, LF2 reduced liver oxidative stress and inflammation, and improved hepatocyte steatosis. To decipher the mechanism behind this therapeutic effect, both the molecular mechanisms and gut microbiota were further analyzed. LF2 inhibited the activation of PI3K-Akt-mTOR axis and decreased the expression of SREBP-1c and PPAR gamma in liver. Interestingly, we found that LF2 and metformin have similar effects on gut microbiota, increasing the proportion of Verrucomicrobia and enriching the abundance of Akkermansia muciniphila, which is beneficial to host health. Collectively, our research clarifies the new application of fucoidan as a functional food for anti-MetS, and provides a new insight for fucoidan to exert systemic therapeutic effects from the perspective of molecular mechanism and gut microbiota.
KeywordFucoidan Metabolic syndrome Gut microbiota
DOI10.1016/j.ijbiomac.2021.10.188
Indexed BySCI
Language英语
Funding ProjectMajor Scientific & Engineering Projects of Innovation in Shandong Province[2019JZZY010818] ; National Natural Science Fundation of China[42176137] ; STS project of the Chinese Academy of Sciences[KFJSTS-QYZD-195] ; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao Pilot National Laboratory for Marine Science and Technology[OF2020NO02] ; K.C. Wong Education Foundation, CAS
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000729557700002
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/177498
Collection实验海洋生物学重点实验室
Corresponding AuthorZhang, Quanbin
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Deng, Zhenzhen,Wu, Ning,Wang, Jing,et al. Low molecular weight fucoidan fraction LF2 improves metabolic syndrome via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of Akkermansia muciniphila in the gut microbiota[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,193:789-798.
APA Deng, Zhenzhen.,Wu, Ning.,Wang, Jing.,Geng, Lihua.,Yue, Yang.,...&Zhang, Quanbin.(2021).Low molecular weight fucoidan fraction LF2 improves metabolic syndrome via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of Akkermansia muciniphila in the gut microbiota.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,193,789-798.
MLA Deng, Zhenzhen,et al."Low molecular weight fucoidan fraction LF2 improves metabolic syndrome via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of Akkermansia muciniphila in the gut microbiota".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 193(2021):789-798.
Files in This Item:
File Name/Size DocType Version Access License
1-s2.0-S014181302102(3607KB)期刊论文出版稿延迟开放CC BY-NC-SAView 2023-7-1后可获取
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, Zhenzhen]'s Articles
[Wu, Ning]'s Articles
[Wang, Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, Zhenzhen]'s Articles
[Wu, Ning]'s Articles
[Wang, Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, Zhenzhen]'s Articles
[Wu, Ning]'s Articles
[Wang, Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0141813021023424-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.