Institutional Repository of Key Laboratory of Marine Ecology & Environmental Sciences, CAS
| microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation | |
Chen, Hao1,2,3,4 ; Wang, Minxiao1,2,3,4; Zhang, Huan1,2,3,4; Wang, Hao1,2,3,4; Zhou, Li1,2,3,4; Zhong, Zhaoshan1,2,3,4,5; Cao, Lei1,2,3,4; Lian, Chao1,2,3,4; Sun, Yan1,2,3,4; Li, Chaolun1,2,3,4,5
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| 2021-12-01 | |
| Source Publication | FISH & SHELLFISH IMMUNOLOGY
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| ISSN | 1050-4648 |
| Volume | 119Pages:420-431 |
| Corresponding Author | Li, Chaolun(lcl@qdio.ac.cn) |
| Abstract | Bathymodiolinae mussels are dominant species in cold seeps and hydrothermal vents and could harbor endosymbionts in gill bacteriocytes. However, mechanisms underlying the symbiosis have remained largely undisclosed for years. In the present study, the global expression pattern of immune-related genes and miRNAs were surveyed in Gigantidas platifrons during bacterial challenges using enriched symbiotic methane oxidation bacteria MOBs or nonsymbiotic Vibrio. As a result, multiple pattern recognition receptors were found differentially expressed at 12 h and 24 h post bacteria challenges and distinctly clustered between stimulations. Dozens of immune effectors along with signal transducers were also modulated simultaneously during MOB or Vibrio challenge. A total of 459 miRNAs were identified in the gill while some were differentially expressed post MOB or nonsymbiotic bacteria challenge. A variety of immune-related genes were annotated as target genes of aforesaid differentially expressed miRNAs. As a result, biological processes including the immune recognition, lysosome activity and bacteria engulfment were suggested to be dynamically modulated by miRNAs in either symbiotic or nonsymbiotic bacteria challenge. It was suggested that G. platifrons mussels could maintain a robust immune response against invading pathogens while establishing symbiosis with chemosynthetic bacteria with the orchestra of immune-related genes and miRNAs. |
| Keyword | Bathymodiolinae mussel Pattern recognition receptor Methane oxidation bacteria Chemosynthetic ecosystem miRNAs Symbiosis |
| DOI | 10.1016/j.fsi.2021.10.025 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS Subject | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| WOS ID | WOS:000714697000006 |
| Publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.qdio.ac.cn/handle/337002/177288 |
| Collection | 海洋生态与环境科学重点实验室 |
| Corresponding Author | Li, Chaolun |
| Affiliation | 1.Chinese Acad Sci, Ctr Deep Sea Res, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 10049, Peoples R China |
| First Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Corresponding Author Affilication | Institute of Oceanology, Chinese Academy of Sciences; Center for Ocean Mega-Science, Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Chen, Hao,Wang, Minxiao,Zhang, Huan,et al. microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation[J]. FISH & SHELLFISH IMMUNOLOGY,2021,119:420-431. |
| APA | Chen, Hao.,Wang, Minxiao.,Zhang, Huan.,Wang, Hao.,Zhou, Li.,...&Li, Chaolun.(2021).microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation.FISH & SHELLFISH IMMUNOLOGY,119,420-431. |
| MLA | Chen, Hao,et al."microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation".FISH & SHELLFISH IMMUNOLOGY 119(2021):420-431. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S105046482100（5618KB） | 期刊论文 | 出版稿 | 延迟开放 | CC BY-NC-SA | View 2023-7-1后可获取 | |
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