IOCAS-IR  > 海洋生态与环境科学重点实验室
microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation
Chen, Hao1,2,3,4; Wang, Minxiao1,2,3,4; Zhang, Huan1,2,3,4; Wang, Hao1,2,3,4; Zhou, Li1,2,3,4; Zhong, Zhaoshan1,2,3,4,5; Cao, Lei1,2,3,4; Lian, Chao1,2,3,4; Sun, Yan1,2,3,4; Li, Chaolun1,2,3,4,5
2021-12-01
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume119Pages:420-431
Corresponding AuthorLi, Chaolun(lcl@qdio.ac.cn)
AbstractBathymodiolinae mussels are dominant species in cold seeps and hydrothermal vents and could harbor endosymbionts in gill bacteriocytes. However, mechanisms underlying the symbiosis have remained largely undisclosed for years. In the present study, the global expression pattern of immune-related genes and miRNAs were surveyed in Gigantidas platifrons during bacterial challenges using enriched symbiotic methane oxidation bacteria MOBs or nonsymbiotic Vibrio. As a result, multiple pattern recognition receptors were found differentially expressed at 12 h and 24 h post bacteria challenges and distinctly clustered between stimulations. Dozens of immune effectors along with signal transducers were also modulated simultaneously during MOB or Vibrio challenge. A total of 459 miRNAs were identified in the gill while some were differentially expressed post MOB or nonsymbiotic bacteria challenge. A variety of immune-related genes were annotated as target genes of aforesaid differentially expressed miRNAs. As a result, biological processes including the immune recognition, lysosome activity and bacteria engulfment were suggested to be dynamically modulated by miRNAs in either symbiotic or nonsymbiotic bacteria challenge. It was suggested that G. platifrons mussels could maintain a robust immune response against invading pathogens while establishing symbiosis with chemosynthetic bacteria with the orchestra of immune-related genes and miRNAs.
KeywordBathymodiolinae mussel Pattern recognition receptor Methane oxidation bacteria Chemosynthetic ecosystem miRNAs Symbiosis
DOI10.1016/j.fsi.2021.10.025
Indexed BySCI
Language英语
WOS Research AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS SubjectFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS IDWOS:000714697000006
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/177288
Collection海洋生态与环境科学重点实验室
Corresponding AuthorLi, Chaolun
Affiliation1.Chinese Acad Sci, Ctr Deep Sea Res, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
5.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
First Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Oceanology, Chinese Academy of Sciences;  Center for Ocean Mega-Science, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Chen, Hao,Wang, Minxiao,Zhang, Huan,et al. microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation[J]. FISH & SHELLFISH IMMUNOLOGY,2021,119:420-431.
APA Chen, Hao.,Wang, Minxiao.,Zhang, Huan.,Wang, Hao.,Zhou, Li.,...&Li, Chaolun.(2021).microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation.FISH & SHELLFISH IMMUNOLOGY,119,420-431.
MLA Chen, Hao,et al."microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation".FISH & SHELLFISH IMMUNOLOGY 119(2021):420-431.
Files in This Item:
File Name/Size DocType Version Access License
1-s2.0-S105046482100(5618KB)期刊论文出版稿延迟开放CC BY-NC-SAView 2023-7-1后可获取
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Hao]'s Articles
[Wang, Minxiao]'s Articles
[Zhang, Huan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Hao]'s Articles
[Wang, Minxiao]'s Articles
[Zhang, Huan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Hao]'s Articles
[Wang, Minxiao]'s Articles
[Zhang, Huan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S1050464821003430-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.