microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation

doi:10.1016/j.fsi.2021.10.025

	microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation
	Chen, Hao1,2,3,4 ; Wang, Minxiao 1,2,3,4; Zhang, Huan 1,2,3,4; Wang, Hao 1,2,3,4; Zhou, Li 1,2,3,4; Zhong, Zhaoshan1,2,3,4,5 ; Cao, Lei1,2,3,4 ; Lian, Chao 1,2,3,4; Sun, Yan 1,2,3,4; Li, Chaolun1,2,3,4,5
	2021-12-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	119 页码:420-431
通讯作者	Li, Chaolun(lcl@qdio.ac.cn)
摘要	Bathymodiolinae mussels are dominant species in cold seeps and hydrothermal vents and could harbor endosymbionts in gill bacteriocytes. However, mechanisms underlying the symbiosis have remained largely undisclosed for years. In the present study, the global expression pattern of immune-related genes and miRNAs were surveyed in Gigantidas platifrons during bacterial challenges using enriched symbiotic methane oxidation bacteria MOBs or nonsymbiotic Vibrio. As a result, multiple pattern recognition receptors were found differentially expressed at 12 h and 24 h post bacteria challenges and distinctly clustered between stimulations. Dozens of immune effectors along with signal transducers were also modulated simultaneously during MOB or Vibrio challenge. A total of 459 miRNAs were identified in the gill while some were differentially expressed post MOB or nonsymbiotic bacteria challenge. A variety of immune-related genes were annotated as target genes of aforesaid differentially expressed miRNAs. As a result, biological processes including the immune recognition, lysosome activity and bacteria engulfment were suggested to be dynamically modulated by miRNAs in either symbiotic or nonsymbiotic bacteria challenge. It was suggested that G. platifrons mussels could maintain a robust immune response against invading pathogens while establishing symbiosis with chemosynthetic bacteria with the orchestra of immune-related genes and miRNAs.
关键词	Bathymodiolinae mussel Pattern recognition receptor Methane oxidation bacteria Chemosynthetic ecosystem miRNAs Symbiosis
DOI	10.1016/j.fsi.2021.10.025
收录类别	SCI
语种	英语
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:000714697000006
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/177288
专题	海洋生态与环境科学重点实验室
通讯作者	Li, Chaolun
作者单位	1.Chinese Acad Sci, Ctr Deep Sea Res, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 5.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
第一作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Chen, Hao,Wang, Minxiao,Zhang, Huan,et al. microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation[J]. FISH & SHELLFISH IMMUNOLOGY,2021,119:420-431.
APA	Chen, Hao.,Wang, Minxiao.,Zhang, Huan.,Wang, Hao.,Zhou, Li.,...&Li, Chaolun.(2021).microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation.FISH & SHELLFISH IMMUNOLOGY,119,420-431.
MLA	Chen, Hao,et al."microRNAs facilitate comprehensive responses of Bathymodiolinae mussel against symbiotic and nonsymbiotic bacteria stimulation".FISH & SHELLFISH IMMUNOLOGY 119(2021):420-431.

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