IOCAS-IR  > 实验海洋生物学重点实验室
The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas
Xin, Lusheng1,2; Liu, Chang3,4,5; Zhang, Huan1; Qiu, Limei1; Wang, Lingling2,3,4,5; Song, Linsheng2,3,4,5
2021-10-01
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
Volume123Pages:8
Corresponding AuthorSong, Linsheng(lshsong@dlou.edu.cn)
AbstractVertebrate interleukin-12 (IL-12) is a heterodimeric cytokine composing of two subunits (p35 and p40). In the present study, a p35-like subunit homolog of vertebrate IL-12 was identified from oyster Crassostrea gigas (designated as CgIL12p35L), with an open reading frame of 411 bp encoding a putative peptide of 136 amino acids. There was a long four-helix chain in CgIL12p35L, which was similar as that in vertebrate IL-12 p35. Comparative genomic analysis showed that there were conservative kinds of syntenic genes flanked CgIL12p35L. The mRNA transcripts of CgIL12p35L were constitutively expressed in various tissues and its mRNA expression level in haemocytes increased significantly after bacteria challenge. The activity of haemolymph to eliminate bacteria from the oysters treated with recombinant CgIL12p35L protein (rCgIL12p35L) in vivo increased significantly. The results collectively indicated that the homolog of vertebrate IL-12 p35 subunit existed in oysters, and it was involved in immune defense against bacteria challenge.
KeywordCrassostrea gigas Cytokine IL-12 IL-12 p35 subunit
DOI10.1016/j.dci.2021.104145
Indexed BySCI
Language英语
Funding ProjectNational Science Foundation of China[U1706204] ; National Key RD Program[2018YFD0900504] ; China Agriculture Research System of MOF and MARA ; Outstanding Talents and Innovative teams of Agricultural Scientific Research in Ministry of Agriculture ; Research Foundation for Distinguished Professor in Liaoning[XLYC1902012] ; Research Foundation for Climbing Scholars in Liaoning and Talented Scholars in Dalian Ocean University
WOS Research AreaFisheries ; Immunology ; Veterinary Sciences ; Zoology
WOS SubjectFisheries ; Immunology ; Veterinary Sciences ; Zoology
WOS IDWOS:000672560600004
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.qdio.ac.cn/handle/337002/177027
Collection实验海洋生物学重点实验室
Corresponding AuthorSong, Linsheng
Affiliation1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266235, Peoples R China
3.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian 116023, Peoples R China
4.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian 116023, Peoples R China
5.Dalian Ocean Univ, Dalian Key Lab Aquat Anim Dis Prevent & Control, Dalian 116023, Peoples R China
First Author AffilicationKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xin, Lusheng,Liu, Chang,Zhang, Huan,et al. The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,123:8.
APA Xin, Lusheng,Liu, Chang,Zhang, Huan,Qiu, Limei,Wang, Lingling,&Song, Linsheng.(2021).The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,123,8.
MLA Xin, Lusheng,et al."The characterization of an interleukin-12 p35 homolog involved in the immune modulation of oyster Crassostrea gigas".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 123(2021):8.
Files in This Item:
File Name/Size DocType Version Access License
1-s2.0-S0145305X2100(7721KB)期刊论文出版稿延迟开放CC BY-NC-SAView 2023-7-1后可获取
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xin, Lusheng]'s Articles
[Liu, Chang]'s Articles
[Zhang, Huan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xin, Lusheng]'s Articles
[Liu, Chang]'s Articles
[Zhang, Huan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xin, Lusheng]'s Articles
[Liu, Chang]'s Articles
[Zhang, Huan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0145305X21001531-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.