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An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway
Li, Shihao1,2,3; Yang, Feifei1; Wang, Fuxuan1; Lv, Xinjia1; Li, Fuhua1,2,3,4
2021-08-01
发表期刊DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN0145-305X
卷号121页码:10
通讯作者Li, Fuhua(fhli@qdio.ac.cn)
摘要The cGAS-STING pathway plays essential roles in detecting cytosolic dsDNA and initiating antiviral and antibacterial responses in vertebrates. However, knowledge about its function in antiviral response of invertebrates is very limited. In the present study, a gene encoding a Mab21-containing protein, a cGAS homologue, was identified from a decapod crustacean Litopenaeus vannamei and designated as LvMab21cp. LvMab21cp was mainly distributed in intestine and hepatopancreas, showing similar expression profile with other genes in the cGASSTING pathway, such as LvSTING and LvIRF. The expression levels of LvMab21cp, LvSTING and LvIRF were up-regulated in intestine and hepatopancreas of shrimp after white spot syndrome virus (WSSV) infection. Knockdown of LvMab21cp by dsRNA-mediated RNA interference could decrease the expression levels of its putative downstream genes, including LvSTING, LvIRF, LvVago4 and LvVago5, and enhance the in vivo propagation of WSSV in shrimp. Overexpression of LvMab21cp and LvSTING in HEK 293T cells activated the expression of mammalian IFNs upon simulation with interferon stimulatory DNA (ISD). These data suggest that LvMab21cp was a cGAS homologue, a member of the shrimp cGAS-STING pathway, and play an important role during WSSV infection. To our knowledge, this is the first report to show the role of the cGAS-STING pathway in the antiviral response of invertebrates, which will provide new insights into the innate immunity of invertebrates.
关键词Mab21-containing protein cGAS-STING pathway WSSV Antiviral response Penaeid shrimp
DOI10.1016/j.dci.2021.104101
收录类别SCI
语种英语
资助项目National Key Research and Development Program of China[2018YFD0900502] ; General Program of National Natural Science Foundation of China[41776158] ; General Program of National Natural Science Foundation of China[31772880] ; China Agriculture Research System-48 (CARS-48) ; China Postdoctoral Science Foundation[2017M612361] ; Distinguished Young Scientists Research Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences[KLEMBDYS01]
WOS研究方向Fisheries ; Immunology ; Veterinary Sciences ; Zoology
WOS类目Fisheries ; Immunology ; Veterinary Sciences ; Zoology
WOS记录号WOS:000663315700004
出版者ELSEVIER SCI LTD
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/176925
专题实验海洋生物学重点实验室
通讯作者Li, Fuhua
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
第一作者单位实验海洋生物学重点实验室;  中国科学院海洋大科学研究中心
通讯作者单位实验海洋生物学重点实验室;  中国科学院海洋大科学研究中心
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GB/T 7714
Li, Shihao,Yang, Feifei,Wang, Fuxuan,et al. An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2021,121:10.
APA Li, Shihao,Yang, Feifei,Wang, Fuxuan,Lv, Xinjia,&Li, Fuhua.(2021).An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,121,10.
MLA Li, Shihao,et al."An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 121(2021):10.
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